Evidence map›Paper›PMID 25760077›Full record

ArticleOncotarget2015

Upregulated lncRNA-UCA1 contributes to progression of hepatocellular carcinoma through inhibition of miR-216b and activation of FGFR1/ERK signaling pathway.

Feng Wang, Hou-Qun Ying, Bang-Shun He, Yu-Qin Pan, Qi-Wen Deng, Hui-Ling Sun, Jie Chen, Xian Liu, Shu-Kui Wang

Registry-linked trialOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05088811 (The Role of Long Non-coding RNAs WRAP53 and UCA-1 as Potential Biomarkers in Diagnosis of Hepatocellular Carcinoma), which is not on this map. Cited by 219 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
219citing papers in PubMed, 10 pooled it
22.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05088811 unknown statusnot on this mapstarted 2021, after this paper: background citation

The Role of Long Non-coding RNAs WRAP53 and UCA-1 as Potential Biomarkers in Diagnosis of Hepatocellular Carcinoma

TypeobservationalSponsorAlexandria UniversityRan2021 to 2022Enrolled80ConditionsHepatocellular Carcinoma, Liver Cirrhosis, Diagnoses DiseaseArmsWRAP53, UCA-1
3 · Its place in the literature

Who cites it

219 citing papers in PubMed, 10 syntheses or guidelines pooled it, 345 citations in OpenAlex.

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  8. Perspectives of long non-coding RNAs in cancer.Molecular biology reports · 2017
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  19. World journal of gastrointestinal oncology · 2024
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159 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Feng WangCentral Laboratory, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Hou-Qun YingMedical College, Southeast University, Nanjing, Jiangsu, China.
Bang-Shun HeCentral Laboratory, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Yu-Qin PanCentral Laboratory, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Qi-Wen DengCentral Laboratory, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Hui-Ling SunDepartment of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu, China.
Jie ChenDepartment of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu, China.
Xian LiuCentral Laboratory, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Shu-Kui WangCentral Laboratory, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Nanjing Medical University · CNNanjing Normal University · CNSoutheast University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The long non-coding RNA (lncRNA) urothelial carcinoma-associated 1 (UCA1) has been recently shown to be dysregulated, which plays an important role in the progression of several cancers. However, the biological role and clinical significance of UCA1 in the carcinogenesis of hepatocellular carcinoma (HCC) remain unclear. Herein, we found that UCA1 was aberrantly upregulated in HCC tissues and associated with TNM stage, metastasis and postoperative survival. UCA1 depletion inhibited the growth and metastasis of HCC cell lines in vitro and in vivo. Furthermore, UCA1 could act as an endogenous sponge by directly binding to miR-216b and downregulation miR-216b expression. In addition, UCA1 could reverse the inhibitory effect of miR-216b on the growth and metastasis of HCC cells, which might be involved in the derepression of fibroblast growth factor receptor 1 (FGFR1) expression, a target gene of miR-216b, and the activation of ERK signaling pathway. Taken together, our data highlights the pivotal role of UCA1 in the tumorigenesis of HCC. Moreover, the present study elucidates a novel lncRNA-miRNA-mRNA regulatory network that is UCA1-miR-216b-FGFR1-ERK signaling pathway in HCC, which may help to lead a better understanding the pathogenesis of HCC and probe the feasibility of lncRNA-directed diagnosis and therapy for this deadly disease.

Indexed as

MAP Kinase Signaling SystemAnimalsCarcinoma, HepatocellularCell Line, TumorCell ProliferationHep G2 CellsHeterograftsHumansLiver NeoplasmsMiceMice, Inbred BALB CMice, NudeMicroRNAsMiddle AgedReceptor, Fibroblast Growth Factor, Type 1RNA, Long NoncodingFGFR1 protein, humanMicroRNAsMIRN216 microRNA, humanReceptor, Fibroblast Growth Factor, Type 1RNA, Long NoncodingUCA1 RNA, humanFGFR1hepatocellular carcinomalncRNAmiR-216bUCA1

Identifiers

PMID25760077
PMCPMC4480724
OpenAlexW1539551850

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.