ReviewCurrent opinion in ophthalmology2015
Emerging techniques for pathogen discovery in endophthalmitis.
Review in Current opinion in ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Contribution of 16S rRNA gene PCR to microbiological diagnosis of endophthalmitis: a retrospective clinical cohort study of 71 vitreous and aqueous humor samples.Journal of ophthalmic inflammation and infection · 2026Article
- Pathogen-Associated Visual Outcomes Following Postprocedure Endophthalmitis.American journal of ophthalmology · 2026Article
- Metagenomic next-generation sequencing: a game-changer in the diagnosis of unique intraocular infections.Eye (London, England) · 2025Article
- Clinical performance of nanopore targeted sequencing for diagnosing endophthalmitis.BMC microbiology · 2025Article
- The diagnosis and treatment progress of infectious endophthalmitis.Eye (London, England) · 2025Review
- Literature- and Experience-Based Consensus for Acute Post-operative Endophthalmitis and Endogenous Endophthalmitis in Taiwan.Ophthalmology and therapy · 2024Article
- A clinical metagenomic study of biopsies from Mexican endophthalmitis patients reveals the presence of complex bacterial communities and a diversity of resistance genes.Access microbiology · 2024Article
- Update on Current Microbiological Techniques for Pathogen Identification in Infectious Endophthalmitis.International journal of molecular sciences · 2022Review
- Microbiological diagnosis of endophthalmitis using nanopore targeted sequencing.Clinical & experimental ophthalmology · 2021Article
- Practical Guidance for Clinical Microbiology Laboratories: Diagnosis of Ocular Infections.Clinical microbiology reviews · 2021Review
- Prognostic Utility of Whole-Genome Sequencing and Polymerase Chain Reaction Tests of Ocular Fluids in Postprocedural Endophthalmitis.American journal of ophthalmology · 2020Article
- The cereus matter of Bacillus endophthalmitis.Experimental eye research · 2020Review
- Targeted High-Throughput Sequencing Identifies Predominantly Fungal Pathogens in Patients with Clinically Infectious, Culture-Negative Endophthalmitis in South India.Microorganisms · 2019Article
- New insights into culture negative endophthalmitis by unbiased next generation sequencing.Scientific reports · 2019Article
- Identifying Corneal Infections in Formalin-Fixed Specimens Using Next Generation Sequencing.Investigative ophthalmology & visual science · 2018Article
- Bacterial and Fungal Endophthalmitis.Clinical microbiology reviews · 2017Review
- Gradient Boosted Decision Tree Classification of Endophthalmitis Versus Uveitis and Lymphoma from Aqueous and Vitreous IL-6 and IL-10 Levels.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2017Article
- Using MALDI-TOF-MS to testMolecular vision · 2017Article
- Sensitivity, specificity and predictive values of anterior chamber tap in cases of bacterial endophthalmitis.Eye and vision (London, England) · 2017Article
- Mitochondria mediates caspase-dependent and independent retinal cell death in Staphylococcus aureus endophthalmitis.Cell death discovery · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewDespite the inability to detect certain organisms and relatively low yield, microbial culture is the current gold standard for the diagnosis of most intraocular infections. Research on alternative molecular diagnostic methods has produced an array of strategies that augment and improve pathogen detection. This review summarizes the most recent literature on this topic. RECENT
findingsThe yield of traditional microbial culture has not improved since the Endophthalmitis Vitrectomy Study results were published 20 years ago. Advances in PCR methods have enabled quantification of pathogen load and screening for multiple organisms at once. More recently, deep sequencing techniques allow highly sensitive detection of any DNA-based life form in a specimen. This offers the promise of not only improved detection of traditional organisms but can also identify organisms not previously associated with endophthalmitis. SUMMARY: Molecular diagnostic methods enhance the results of microbial culture and may become the new standard in the diagnosis of intraocular infections.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.