ArticleFaraday discussions2015
Selective TERS detection and imaging through controlled plasmonics.
Article in Faraday discussions, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Catching COVID: Engineering Peptide-Modified Surface-Enhanced Raman Spectroscopy Sensors for SARS-CoV-2.ACS sensors · 2021Article
- Surface Enhanced Raman Scattering Selectivity in Proteins Arises from Electron Capture and Resonant Enhancement of Radical Species.The journal of physical chemistry. C, Nanomaterials and interfaces · 2020Article
- Probing Membrane Receptors with Enhanced Raman Imaging.Proceedings of SPIE--the International Society for Optical Engineering · 2018Article
- Bioanalytical applications of surface-enhanced Raman spectroscopy:Reviews in analytical chemistry · 2017Article
- Probing Membrane Receptor-Ligand Specificity with Surface- and Tip- Enhanced Raman Scattering.Analytical chemistry · 2017Article
- Photothermal Microscopy of Coupled Nanostructures and the Impact of Nanoscale Heating in Surface Enhanced Raman Spectroscopy.The journal of physical chemistry. C, Nanomaterials and interfaces · 2017Article
- Selective Detection of RGD-Integrin Binding in Cancer Cells Using Tip Enhanced Raman Scattering Microscopy.Analytical chemistry · 2016Article
- Alizarin Dye based ultrasensitive plasmonic SERS probe for trace level Cadmium detection in drinking water.Sensors and actuators. B, Chemical · 2016Article
- Targeted-TERS detection of integrin receptors on human cancer cells.Cancer cell & microenvironment · 2016Article
- Experimental correlation of electric fields and Raman signals in SERS and TERS.Proceedings of SPIE--the International Society for Optical Engineering · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Enhanced Raman spectroscopy offers capabilities to detect molecules in the complex molecular environments and image chemical heterogeneity in a wide range of samples. It has been shown that plasmonic interactions between a TERS tip and a metal surface produce significant enhancements. In this report we show how SERS spectra from purified molecules can be used to selectively image proteins on surfaces and in cell membranes. The SERS response from the purified protein can be used to create a multivariate regression model that can be applied to nanoparticles that bind to protein receptors. Filtering the observed TERS spectra with the regression model can then selectively image the protein receptor. Experiments with mutant proteins suggest that key amino acids provide significant contributions to the observed TERS signal, which enables the differentiation of protein receptors. These results demonstrate the selectivity that can be obtained in TERS images through a controlled plasmonic interaction. This approach has further implications for identifying membrane receptors that bind specific molecules relevant to drug targeting and chemical signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.