ArticleBioarchitecture2014
Emergent properties of composite semiflexible biopolymer networks.
Article in Bioarchitecture, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Interspecies interactions in dual, fibrous gels enable control of gel structure and rheology.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Proliferation of Human Cervical Cancer Cells Responds to Surface Properties of Bicomponent Polymer Coatings.Nanomaterials (Basel, Switzerland) · 2025Article
- Scale-dependent interactions enable emergent microrheological stress response of actin-vimentin composites.Soft matter · 2024Article
- How cytoskeletal crosstalk makes cells move: Bridging cell-free and cell studies.Biophysics reviews · 2024Review
- Multiscale architecture: Mechanics of composite cytoskeletal networks.Biophysics reviews · 2022Review
- Effects of Vimentin Intermediate Filaments on the Structure and Dynamics of In Vitro Multicomponent Interpenetrating Cytoskeletal Networks.Physical review letters · 2021Article
- Review
- The vimentin cytoskeleton: when polymer physics meets cell biology.Physical biology · 2020Article
- Qualitative analysis of contribution of intracellular skeletal changes to cellular elasticity.Cellular and molecular life sciences : CMLS · 2020Review
- Scaling up single-cell mechanics to multicellular tissues - the role of the intermediate filament-desmosome network.Journal of cell science · 2020Review
- Glassy dynamics in composite biopolymer networks.Soft matter · 2018Article
- Co-Entangled Actin-Microtubule Composites Exhibit Tunable Stiffness and Power-Law Stress Relaxation.Biophysical journal · 2018Article
- Mechanical Properties of the Cytoskeleton and Cells.Cold Spring Harbor perspectives in biology · 2017Review
- Nonlinear mechanics of hybrid polymer networks that mimic the complex mechanical environment of cells.Nature communications · 2017Article
- Vimentin fibers orient traction stress.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Intermediate Filaments: Structure and Assembly.Cold Spring Harbor perspectives in biology · 2016Review
- Mechanics and dynamics of reconstituted cytoskeletal systems.Biochimica et biophysica acta · 2015Review
- Thematic Minireview Series: The State of the Cytoskeleton in 2015.The Journal of biological chemistry · 2015Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The semiflexible polymers filamentous actin (F-actin) and intermediate filaments (IF) both form complex networks within the cell, and together are key determinants of cellular stiffness. While the mechanics of F-actin networks together with stiff microtubules have been characterized, the interplay between F-actin and IF networks is largely unknown, necessitating the study of composite networks using mixtures of semiflexible biopolymers. We employ bulk rheology in a simplified in vitro system to uncover the fundamental mechanical interactions between networks of the 2 semiflexible polymers, F-actin and vimentin IF. Surprisingly, co-polymerization of actin and vimentin can produce composite networks either stronger or weaker than pure F-actin networks. We show that this effect occurs through steric constraints imposed by IF on F-actin during network formation and filament crosslinking, highlighting novel emergent behavior in composite semiflexible networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.