ArticleBioMed research international2015
Evaluation of hemagglutination activity of chitosan nanoparticles using human erythrocytes.
Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 72 citations in OpenAlex.
- Procoagulant and Antimicrobial Effects of Chitosan in Wound Healing.International journal of molecular sciences · 2021Trial
- Chitosan-Nanomaterials (Basel, Switzerland) · 2025Article
- Multilayer Adjuvanted Influenza Protein Nanoparticles Improve Intranasal Delivery and Antigen-Specific Immunity.ACS nano · 2025Article
- The renoprotective activity of amikacin-gamma-amino butyric acid-chitosan nanoparticles: a comparative study.Inflammopharmacology · 2024Article
- Chitosan Soft Matter Vesicles Loaded with Acetaminophen as Promising Systems for Modified Drug Release.Molecules (Basel, Switzerland) · 2023Article
- Poly(ethylene imine)-chitosan carbon dots: study of its physical-chemical properties and biological in vitro performance.Discover nano · 2023Article
- Assessment of antimicrobial and anthelmintic activity of silver nanoparticles bio-synthesized from Viscum orientale leaf extract.BMC complementary medicine and therapies · 2023Article
- Chitosan-graphene quantum dot based active film as smart wound dressing.Journal of drug delivery science and technology · 2023Article
- Therapy of Organophosphate Poisoning via Intranasal Administration of 2-PAM-Loaded Chitosomes.Pharmaceutics · 2022Article
- Curcumin coated 3D biocomposite scaffolds based on chitosan and cellulose for diabetic wound healing.Heliyon · 2022Article
- Multiple Roles of Chitosan in Mucosal Drug Delivery: An Updated Review.Marine drugs · 2022Review
- Application of chitosan-based nanoparticles in skin wound healing.Asian journal of pharmaceutical sciences · 2022Review
- Polymeric nanoparticles in the diagnosis and treatment of myocardial infarction: Challenges and future prospects.Materials today. Bio · 2022Review
- Experimental Design Based Optimization and Ex Vivo Permeation of Desmopressin Acetate Loaded Elastic Liposomes Using Rat Skin.Pharmaceutics · 2021Article
- Development of pH-Responsive Biopolymeric Nanocapsule for Antibacterial Essential Oils.International journal of molecular sciences · 2020Article
- Evidence Supporting the Safety of Pegylated Diethylaminoethyl-Chitosan Polymer as a Nanovector for Gene Therapy Applications.International journal of nanomedicine · 2020Article
- Chitosan Nanoparticles: Shedding Light on Immunotoxicity and Hemocompatibility.Frontiers in bioengineering and biotechnology · 2020Article
- The Hemocompatibility of Nanoparticles: A Review of Cell-Nanoparticle Interactions and Hemostasis.Cells · 2019Review
- Chitosan-Based Bioactive Hemostatic Agents with Antibacterial Properties-Synthesis and Characterization.Molecules (Basel, Switzerland) · 2019Article
- Exploiting chitosan and gold nanoparticles for antimycobacterial activity of in silico identified antimicrobial motif of human neutrophil peptide-1.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chitosan is a polysaccharide composed of randomly distributed chains of β-(1-4) D-glucosamine and N-acetyl-D-glucosamine. This compound is obtained by partial or total deacetylation of chitin in acidic solution. The chitosan-based hemostatic agents have been gaining much attention in the management of bleeding. The aim of this study was to evaluate in vitro hemagglutination activity of chitosan nanoparticles using human erythrocytes. The preparation of nanoparticles was achieved by ionotropic gelification technique followed by neutralization with NaOH 1 mol/L(-1). The hemagglutination activity was performed on a solution of 2% erythrocytes (pH 7.4 on PBS) collected from five healthy volunteers. The hemolysis determination was made by spectrophotometric analysis. Chitosan nanoparticle solutions without NaOH addition changed the reddish colour of the wells into brown, suggesting an oxidative reaction of hemoglobin and possible cell lysis. All neutralized solutions of chitosan nanoparticles presented positive haemagglutination, without any change in reaction color. Chitosan nanoparticles presented hemolytic activity ranging from 186.20 to 223.12%, while neutralized solutions ranged from 2.56 to 72.54%, comparing to distilled water. Results highlight the need for development of new routes of synthesis of chitosan nanoparticles within human physiologic pH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.