Distinct malignant behaviors of mouse myogenic tumors induced by different oncogenetic lesions.

Simone Hettmer, Roderick T Bronson, Amy J Wagers

Open access · goldAbstract read

In one paragraph

Article in Frontiers in oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

0.7field-weighted citation impact, top 26% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

Clinical and mutational spectrum of highly differentiated, paired box 3:forkhead box protein o1 fusion-negative rhabdomyosarcoma: A report from the Children's Oncology Group.Cancer · 2018
Article
Myogenic regulatory transcription factors regulate growth in rhabdomyosarcoma.eLife · 2017
Article
Hedgehog-driven myogenic tumors recapitulate skeletal muscle cellular heterogeneity.Experimental cell research · 2016
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Simone HettmerDivision of Pediatric Hematology and Oncology, Department of Pediatric and Adolescent Medicine, University Medical Center Freiburg , Freiburg , Germany ; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University , Boston, MA , USA ; Howard Hughes Medical Institute , Chevy Chase, MD , USA ; Joslin Diabetes Center , Boston, MA , USA.

Roderick T BronsonDepartment of Biomedical Sciences, Tufts University Veterinary School , North Grafton, MA , USA.

Amy J WagersDepartment of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University , Boston, MA , USA ; Howard Hughes Medical Institute , Chevy Chase, MD , USA ; Joslin Diabetes Center , Boston, MA , USA.

Joslin Diabetes Center · USTufts University · USUniversity Medical Center Freiburg · DE

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI JEAN E. SCHAFFER · 1986 to 2026

$50.5M

NIDDK NIH HHS P30 DK036836Wellcome Trust

6 · The paper itself

Abstract

Rhabdomyosarcomas (RMS) are heterogeneous cancers with myogenic differentiation features. The cytogenetic and mutational aberrations in RMS are diverse. This study examined differences in the malignant behavior of two genetically distinct and disease-relevant mouse myogenic tumor models. Kras; p1619(null) myogenic tumors, initiated by expression of oncogenic Kras in p16p19(null) mouse satellite cells, were metastatic to the lungs of the majority of tumor-bearing animals and repopulated tumors in seven of nine secondary recipients. In contrast, SmoM2 tumors, initiated by ubiquitous expression of a mutant Smoothened allele, did not metastasize and repopulated tumors in 2 of 18 recipients only. In summary, genetically distinct myogenic tumors in mice exhibit marked differences in malignant behavior.

Indexed as

metastasismyogenic differentiationrhabdomyosarcomatransplantation

Identifiers

PMID25759794

DOI10.3389/fonc.2015.00050

PMCPMC4338657

OpenAlexW2042126548

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.