Evidence map›Paper›PMID 25759715›Full record

ArticleDementia and geriatric cognitive disorders extra

Aerobic physical exercise improved the cognitive function of elderly males but did not modify their blood homocysteine levels.

Hanna Karen M Antunes, Marco Túlio De Mello, Valdir de Aquino Lemos, Ruth Ferreira Santos-Galduróz, Luciano Camargo Galdieri, Orlando Francisco Amodeo Bueno, Sergio Tufik, Vânia D'Almeida

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Dementia and geriatric cognitive disorders extra. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 6 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 6 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  6. Pooled it
  7. Trial
  8. Article
  9. Review
  10. Article
  11. Review
  12. Strategies for dementia prevention: latest evidence and implications.Therapeutic advances in chronic disease · 2017
    Review
  13. Effects of a physical fitness program on memory and blood viscosity in sedentary elderly men.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Hanna Karen M AntunesDepartamento de Biociências, Universidade Federal de São Paulo - UNIFESP, Santos, Santo André, Brazil ; Centro de Estudos em Psicobiologia e Exercício - CEPE, São Paulo, Santo André, Brazil.
Marco Túlio De MelloDepartamento de Psicobiologia, Universidade Federal de São Paulo - UNIFESP, Santo André, Brazil ; Centro de Estudos em Psicobiologia e Exercício - CEPE, São Paulo, Santo André, Brazil.
Valdir de Aquino LemosDepartamento de Psicobiologia, Universidade Federal de São Paulo - UNIFESP, Santo André, Brazil ; Centro de Estudos em Psicobiologia e Exercício - CEPE, São Paulo, Santo André, Brazil.
Ruth Ferreira Santos-GaldurózCentro de Matemática, Computação e Cognição, Universidade Federal do ABC - UFABC, Santo André, Brazil.
Luciano Camargo GaldieriSt. John's University, Queens, New York, N.Y., USA.
Orlando Francisco Amodeo BuenoDepartamento de Psicobiologia, Universidade Federal de São Paulo - UNIFESP, Santo André, Brazil.
Sergio TufikDepartamento de Psicobiologia, Universidade Federal de São Paulo - UNIFESP, Santo André, Brazil.
Vânia D'AlmeidaDepartamento de Psicobiologia, Universidade Federal de São Paulo - UNIFESP, Santo André, Brazil.
Universidade Federal de São Paulo · BRCentro de Estudos em Psicologia da Saúde · BRSt. John's University · USUniversidade Federal do ABC · BRUniversidade Metropolitana de Santos · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPhysical exercise influences homocysteine (Hcy) concentrations, cognitive function and the metabolic profile. The purpose of this study was to investigate the influence of regular physical exercise on Hcy levels, the metabolic profile and cognitive function in healthy elderly males before and after an endurance exercise program.

methodsForty-five healthy and sedentary volunteers were randomized into 2 groups: (1) a control group asked not to change their normal everyday activities and not to start any regular physical exercise program and (2) an experimental group trained at a heart rate intensity corresponding to ventilatory threshold 1 (VT-1) for 60 min/day 3 times weekly on alternate days for 6 months using a cycle ergometer. All volunteers underwent cognitive evaluations, blood sample analyses and ergospirometric assessments.

resultsA significant improvement in cognitive function was observed in the experimental group compared with the control group (p < 0.05). No significant changes in Hcy levels were observed in the experimental group (p > 0.05), but there was a significant increase in peak oxygen consumption and workload at VT-1 as well as a significant improvement in cholesterol, triglycerides, HDL, glucose, alkaline phosphatase, urea, T3, T4 and prostate-specific antigen compared with the control group (p < 0.05).

conclusionThe data suggest that a physical exercise program does not reduce Hcy levels in healthy elderly males, although it improves the cardiovascular and metabolic profile as well as cognitive function.

Indexed as

Aerobic trainingCognitive functionElderly subjectsHomocysteineMetabolic profilePhysical exercise

Identifiers

PMID25759715
PMCPMC4335628
OpenAlexW2074127930

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.