ArticleFrontiers in physiology2015
Changes in mitochondrial function and mitochondria associated protein expression in response to 2-weeks of high intensity interval training.
Article in Frontiers in physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Quantitative assessment of efficacy and evaluation of feasibility of exercise training protocols in adult and pediatric primary mitochondrial disease.BMC medicine · 2026Pooled it
- Optimizing the Interaction of Exercise Volume and Metformin to Induce a Clinically Significant Reduction in Metabolic Syndrome Severity: A Randomised Trial.International journal of environmental research and public health · 2020Trial
- Mitochondrial respiration variability and simulations in human skeletal muscle: The Gene SMART study.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Trial
- Physiological responses to incremental, interval, and continuous counterweighted single-leg and double-leg cycling at the same relative intensities.European journal of applied physiology · 2017Trial
- Skeletal muscle mitochondrial bioenergetics in pregnancy: a comparison of in vivo and in vitro outcomes.Journal of the Endocrine Society · 2026Article
- UVA Irradiation Promotes ROS-Mediated Formation of the Common Deletion in Mitochondrial DNA.Life (Basel, Switzerland) · 2026Article
- Effect of (-)-Epicatechin on Mitochondrial Homeostasis in Skeletal Muscle of Female Obese Rats.Molecules (Basel, Switzerland) · 2026Article
- Polarized or threshold training: is there a superior training intensity distribution to improve V̇OJournal of physiology and biochemistry · 2025Article
- Sulforaphane Restores Mitochondrial β-Oxidation and Reduces Renal Lipid Accumulation in a Model of Releasing Unilateral Ureteral Obstruction.Antioxidants (Basel, Switzerland) · 2025Article
- Inhaled formoterol impairs aerobic exercise capacity in endurance-trained individuals: a randomised controlled trial.ERJ open research · 2023Article
- The effect of pre-exercise alkalosis on lactate/pH regulation and mitochondrial respiration following sprint-interval exercise in humans.Frontiers in physiology · 2023Article
- Effects of low and high intensity interval training exercises on VOJournal of musculoskeletal & neuronal interactions · 2022Article
- Oxidative Stress and Hypoxia Modify Mitochondrial Homeostasis During Glaucoma.Antioxidants & redox signaling · 2021Article
- Feasibility of high-intensity interval training in patients with left ventricular assist devices: a pilot study.ESC heart failure · 2021Article
- MitoQ and CoQ10 supplementation mildly suppresses skeletal muscle mitochondrial hydrogen peroxide levels without impacting mitochondrial function in middle-aged men.European journal of applied physiology · 2020Article
- Protein arginine methyltransferase biology in humans during acute and chronic skeletal muscle plasticity.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Muscle-Specific Sensitivity to Voluntary Physical Activity and Detraining.Frontiers in physiology · 2019Article
- Locomotor Muscles in COPD: The Rationale for Rehabilitative Exercise Training.Frontiers in physiology · 2019Review
- Small Molecule Oligopeptides Isolated from Walnut (Molecules (Basel, Switzerland) · 2018Article
- Training-Induced Changes in Mitochondrial Content and Respiratory Function in Human Skeletal Muscle.Sports medicine (Auckland, N.Z.) · 2018Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeHigh-intensity short-duration interval training (HIT) stimulates functional and metabolic adaptation in skeletal muscle, but the influence of HIT on mitochondrial function remains poorly studied in humans. Mitochondrial metabolism as well as mitochondrial-associated protein expression were tested in untrained participants performing HIT over a 2-week period.
methodsEight males performed a single-leg cycling protocol (12 × 1 min intervals at 120% peak power output, 90 s recovery, 4 days/week). Muscle biopsies (vastus lateralis) were taken pre- and post-HIT. Mitochondrial respiration in permeabilized fibers, citrate synthase (CS) activity and protein expression of peroxisome proliferator-activated receptor gamma coactivator (PGC-1α) and respiratory complex components were measured.
resultsHIT training improved peak power and time to fatigue. Increases in absolute oxidative phosphorylation (OXPHOS) capacities and CS activity were observed, but not in the ratio of CCO to the electron transport system (CCO/ETS), the respiratory control ratios (RCR-1 and RCR-2) or mitochondrial-associated protein expression. Specific increases in OXPHOS flux were not apparent after normalization to CS, indicating that gross changes mainly resulted from increased mitochondrial mass.
conclusionOver only 2 weeks HIT significantly increased mitochondrial function in skeletal muscle independently of detectable changes in mitochondrial-associated and mitogenic protein expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.