ArticleFrontiers in neuroscience2015
Genetic manipulation of reptilian embryos: toward an understanding of cortical development and evolution.
Article in Frontiers in neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 33 citations in OpenAlex.
- Expanded iOn switch toolkit enables flexible clonal labeling and dynamic imaging in model and non-model animals.Communications biology · 2026Article
- Experimental Neurogenesis in the Embryos of the Gecko Paroedura picta.Methods in molecular biology (Clifton, N.J.) · 2025Article
- The bearded dragon Pogona vitticeps.Nature methods · 2024Article
- ETV2 induces endothelial, but not hematopoietic, lineage specification in birds.Life science alliance · 2024Article
- CRISPR-Cas9 Gene Editing in Lizards through Microinjection of Unfertilized Oocytes.Cell reports · 2019Article
- Madagascar ground gecko genome analysis characterizes asymmetric fates of duplicated genes.BMC biology · 2018Article
- Skull Development, Ossification Pattern, and Adult Shape in the Emerging Lizard Model OrganismFrontiers in physiology · 2018Article
- Appendages and gene regulatory networks: Lessons from the limbless.Genesis (New York, N.Y. : 2000) · 2018Review
- Melanoblast development coincides with the late emerging cells from the dorsal neural tube in turtle Trachemys scripta.Scientific reports · 2017Article
- Pattern of Neurogenesis and Identification of Neuronal Progenitor Subtypes during Pallial Development inFrontiers in neuroanatomy · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mammalian neocortex is a remarkable structure that is characterized by tangential surface expansion and six-layered lamination. However, how the mammalian neocortex emerged during evolution remains elusive. Because all modern reptiles have a homolog of the neocortex at the dorsal pallium, developmental analyses of the reptilian cortex are valuable to explore the origin of the neocortex. However, reptilian cortical development and the underlying molecular mechanisms remain unclear, mainly due to technical difficulties with sample collection and embryonic manipulation. Here, we introduce a method of embryonic manipulations for the Madagascar ground gecko and Chinese softshell turtle. We established in ovo electroporation and an ex ovo culture system to address neural stem cell dynamics, neuronal differentiation and migration. Applications of these techniques illuminate the developmental mechanisms underlying reptilian corticogenesis, which provides significant insight into the evolutionary steps of different types of cortex and the origin of the mammalian neocortex.
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