ArticleClinical epidemiology2015
Statin prescription patterns, adherence, and attainment of cholesterol treatment goals in routine clinical care: a Danish population-based study.
Article in Clinical epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Prevalence of statin intolerance: a meta-analysis.European heart journal · 2022 · on this mapPooled it
- Effect of Statins onGE Portuguese journal of gastroenterology · 2022Pooled it
- Impact of postdiagnostic statin use on ovarian cancer mortality: A systematic review and meta-analysis of observational studies.British journal of clinical pharmacology · 2018Pooled it
- Statins and New-Onset Diabetes in Cardiovascular and Kidney Disease Cohorts: A Meta-Analysis.Cardiorenal medicine · 2018 · on this mapPooled it
- Cardiovascular Risk Estimation and Statin Adherence: A Historical Cohort Study.Medical decision making : an international journal of the Society for Medical Decision Making · 2026Article
- Pharmacogenetic Associations with Statin Regimen Modification, Intolerance, and Adverse Outcomes in Coronary Artery Disease Patients.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Clinical Characteristics of Patients With Statin Discontinuation in Korea: A Nationwide Population-Based Study.Journal of lipid and atherosclerosis · 2024Article
- Use of statins and risk of myeloproliferative neoplasms: a Danish nationwide case-control study.Blood advances · 2023Article
- Evaluation of LDL goal achievement in statin consumption, south east of Iran.Scientific reports · 2021Article
- The impact of hospital-diagnosed depression or use of antidepressants on treatment initiation, adherence and HbADiabetologia · 2021Article
- Preventive drug therapy and contralateral breast cancer: summary of the evidence of clinical trials and observational studies.Acta oncologica (Stockholm, Sweden) · 2019Review
- Lipophilic Statins and Risk for Hepatocellular Carcinoma and Death in Patients With Chronic Viral Hepatitis: Results From a Nationwide Swedish Population.Annals of internal medicine · 2019Article
- Prescribing pattern of statins for primary prevention of cardiovascular diseases in patients with type 2 diabetes: insights from Ethiopia.BMC research notes · 2019Article
- Patterns of statin utilisation for new users and market dynamics in South Korea: a 13-year retrospective cohort study.BMJ open · 2019Article
- Adherence to Statin Therapy and Attainment of LDL Cholesterol Goal Among Patients with Type 2 Diabetes and Dyslipidemia.Patient preference and adherence · 2019Article
- Statin use and risk of contralateral breast cancer: a nationwide cohort study.British journal of cancer · 2018Article
- Characterization of Statin Low-Density Lipoprotein Cholesterol Dose-Response Using Electronic Health Records in a Large Population-Based Cohort.Circulation. Genomic and precision medicine · 2018Article
- Statin-associated myopathy. Assessment of frequency based on data of all statutory health insurance funds in Germany.Pharmacology research & perspectives · 2018Article
- Atorvastatin enhances radiosensitivity in hypoxia-induced prostate cancer cells related with HIF-1α inhibition.Bioscience reports · 2017Article
- 10-year trends in statin utilization in Taiwan: a retrospective study using Taiwan's National Health Insurance Research Database.BMJ open · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
purposeTo examine the annual rate and cumulative prevalence of statin use in Denmark 2004-10, including adherence of use and attainment of cholesterol targets.
methodsWe included all individuals aged 18-86 years with a first statin prescription in Northern Denmark in 2004-10. We calculated the annual rate and cumulative prevalence of statin use. We examined cholesterol values before and after start of statins and the proportion reaching targets according to European guidelines and cardiovascular risk group.
resultsThe study population consisted of 161,646 new statin users (51% men; median age 62 years). The peak rate of new statin initiators occurred in 2008, and a cumulative prevalence of 94 users per 1,000 population was reached in 2010. In total, 98% of new users started with simvastatin. Eighty-eight percent (142,897) did not switch statin type during follow-up. Overall persistence was 84%. The reduction in median total cholesterol in new statin users was 28% (from 6.3 mmol/L to 4.5 mmol/L), while it was 43% (from 4.0 mmol/L to 2.3 mmol/L) for low-density lipoprotein cholesterol. Among patients with very high cardiovascular risk, 66% attained the recommended total cholesterol target; corresponding figures were 74% among high-risk patients and 80% among low- to moderate-risk patients. Corresponding figures for low-density lipoprotein cholesterol were 54%, 82%, and 88%, respectively.
conclusionsStatin use has become very prevalent in Danish adults, with high adherence. Cholesterol reduction after statin initiation is similar to that found in clinical trials, yet a substantial proportion of patients does not reach target cholesterol levels.
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