Evidence map›Paper›PMID 25759567›Full record

ArticlePatient preference and adherence2015

Extent and reasons for nonadherence to antihypertensive, cholesterol, and diabetes medications: the association with depressive symptom burden in a sample of American veterans.

Hollis J Weidenbacher, Christopher A Beadles, Matthew L Maciejewski, Bryce B Reeve, Corrine I Voils

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Article in Patient preference and adherence, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
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15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Observational
  5. Assessing forgetfulness and polypharmacy and their impact on health-related quality of life among patients with hypertension and dyslipidemia in Greece during the COVID-19 pandemic.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022
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  9. Article
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  11. Article
  12. Comparison of Student and Patient Perceptions for Medication Non-adherence.American journal of pharmaceutical education · 2018
    Article
  13. Identifying targets for cardiovascular medication adherence interventions through latent class analysis.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2018
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hollis J WeidenbacherCenter for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, NC, USA.
Christopher A BeadlesCenter for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, NC, USA ; Department of Health Policy and Management, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC, USA.
Matthew L MaciejewskiCenter for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, NC, USA ; Division of General Internal Medicine, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Bryce B ReeveDepartment of Health Policy and Management, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC, USA.
Corrine I VoilsCenter for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, NC, USA ; Division of General Internal Medicine, Department of Medicine, Duke University Medical Center, Durham, NC, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePersons with depressive symptoms generally have higher rates of medication nonadherence than persons without depressive symptoms. However, little is known about whether this association differs by comorbid medical condition or whether reasons for nonadherence differ by depressive symptoms or comorbid medical condition.

methodsSelf-reported extent of nonadherence, reasons for nonadherence, and depressive symptoms among 1,026 veterans prescribed medications for hypertension, dyslipidemia, and/or type 2 diabetes were assessed.

resultsIn multivariable logistic regression adjusted for clinical and demographic factors, the odds of nonadherence were higher among participants with high depressive symptom burden for dyslipidemia (n=848; odds ratio [OR]: 1.42, P=0.03) but not hypertension (n=916; OR: 1.24, P=0.15), or type 2 diabetes (n=447; OR: 1.15, P=0.51). Among participants reporting nonadherence to antihypertensive and antilipemic medications, those with greater depressive symptom burden had greater odds of endorsing medication nonadherence reasons related to negative expectations and excessive economic burden. Neither extent of nonadherence nor reasons for nonadherence differed by depressive symptom burden among patients with diabetes.

conclusionThese findings suggest that clinicians may consider tailoring interventions to improve adherence to antihypertensive and antilipemic medications to specific medication concerns of participants with depressive symptoms.

Indexed as

adherencechronic conditionscompliancedepressionheterogeneity

Identifiers

PMID25759567
PMCPMC4346007

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.