Evidence map›Paper›PMID 25759554›Full record

ArticleWorld journal of gastroenterology2015

N-acetylcysteine treats intravenous amiodarone induced liver injury.

Matthew L Mudalel, Kartikeya P Dave, James P Hummel, Steven F Solga

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Drug-Induced Liver Injury: An Institutional Case Series and Review of Literature.Journal of investigative medicine high impact case reports
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Matthew L MudalelMatthew L Mudalel, Steven F Solga, Department of Medicine, Division of Gastroenteorlogy, St. Luke's University Hospital and Temple School of Medicine, Bethlehem, PA 18015, United States.
Kartikeya P DaveMatthew L Mudalel, Steven F Solga, Department of Medicine, Division of Gastroenteorlogy, St. Luke's University Hospital and Temple School of Medicine, Bethlehem, PA 18015, United States.
James P HummelMatthew L Mudalel, Steven F Solga, Department of Medicine, Division of Gastroenteorlogy, St. Luke's University Hospital and Temple School of Medicine, Bethlehem, PA 18015, United States.
Steven F SolgaMatthew L Mudalel, Steven F Solga, Department of Medicine, Division of Gastroenteorlogy, St. Luke's University Hospital and Temple School of Medicine, Bethlehem, PA 18015, United States.
Montefiore Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a case of intravenous (IV) amiodarone drug induced liver injury (DILI). The patient received IV N-acetylcysteine (NAC) which resulted in a rapid improvement in liver enzymes. While the specific mechanisms for the pathogenesis of IV amiodarone DILI and the therapeutic action of IV NAC are both unknown, this case strongly implies at least some commonality. Because IV amiodarone is indicated for the treatment of serious cardiac arrhythmias in an intensive care unit setting, some degree of ischemic hepatitis is likely a cofactor in most cases.

Indexed as

AcetylcysteineAgedAmiodaroneAnti-Arrhythmia AgentsAntioxidantsBiomarkersChemical and Drug Induced Liver InjuryFatal OutcomeFemaleHumansInfusions, IntravenousInjections, IntravenousLiverLiver Function TestsOxidative StressTime FactorsAcetylcysteineAmiodaroneAnti-Arrhythmia AgentsAntioxidantsBiomarkersAmiodaroneDrug induced liver injuryLiver enzymesN-acetylcysteinePathogenesis

Identifiers

PMID25759554
PMCPMC4351236
OpenAlexW2328278876

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.