Evidence map›Paper›PMID 25759532›Full record

ArticleWorld journal of gastroenterology2015

Angiopoietin and vascular endothelial growth factor expression in colorectal disease models.

Wei-Xin Liu, Shou-Zhi Gu, Shen Zhang, Yi Ren, Li-Xuan Sang, Cong Dai

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Wei-Xin LiuWei-Xin Liu, Shen Zhang, Yi Ren, Li-Xuan Sang, Cong Dai, Department of Gastroenterology, First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning Province, China.
Shou-Zhi GuWei-Xin Liu, Shen Zhang, Yi Ren, Li-Xuan Sang, Cong Dai, Department of Gastroenterology, First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning Province, China.
Shen ZhangWei-Xin Liu, Shen Zhang, Yi Ren, Li-Xuan Sang, Cong Dai, Department of Gastroenterology, First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning Province, China.
Yi RenWei-Xin Liu, Shen Zhang, Yi Ren, Li-Xuan Sang, Cong Dai, Department of Gastroenterology, First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning Province, China.
Li-Xuan SangWei-Xin Liu, Shen Zhang, Yi Ren, Li-Xuan Sang, Cong Dai, Department of Gastroenterology, First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning Province, China.
Cong DaiWei-Xin Liu, Shen Zhang, Yi Ren, Li-Xuan Sang, Cong Dai, Department of Gastroenterology, First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning Province, China.
China Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate angiopoietin (Ang) and vascular endothelial growth factor (VEGF) expression in rats with ulcerative colitis (UC) and colorectal cancer (CRC).

methodsDysplasia and cancer were investigated in rats that received three cycles of 3.5% dextran sulfate sodium (DSS) in drinking water for 7 d followed by distilled water for 14 d after intraperitoneal pretreatment with 20 mg/kg 1,2-dimethylhydrazine (DMH) (CRC group). Colitis was investigated in rats that received three cycles of 3.5% DSS in drinking water for 7 d followed by distilled water for 14 d after intraperitoneal pretreatment with saline (UC group). Rats without DSS or DMH treatment served as controls. Expression of the tyrosine kinase with immunoglobulin-like and EGF-like domains (Tie)-2 and its ligands, Ang-1 and Ang-2, as well as VEGF were evaluated in the colorectum by Western blotting.

resultsCompared with rats in the control group, rats in the CRC and UC groups developed the symptoms of acute colitis with diarrhea, rectal bleeding, wasting, and loss of body weight (P < 0.05). In addition, the mean length of colorectum of CRC and UC rats was significantly shorter than that of control rats (8.29 ± 0.21 and 8.31 ± 0.86, respectively, vs 12.34 ± 0.12 cm; P < 0.05). Furthermore, rats in the CRC group, but not in the UC or control groups, developed multiple tumors in the colorectal region. Western blot analysis revealed that rats in the CRC and UC groups had markedly increased protein levels of Ang-1, Ang-2, Tie-2, and VEGF in the colorectum compared to rats in the control group.

conclusionIncreased expression of Ang-1, Ang-2, Tie-2, and VEGF in ulcerative colitis-derived colorectal cancer might lead to chronic colitis and pathologic angiogenesis in rats.

Indexed as

1,2-DimethylhydrazineAngiopoietin-1Angiopoietin-2AnimalsColitis, UlcerativeColonColorectal NeoplasmsDextran SulfateDisease Models, AnimalMaleRats, WistarReceptor, TIE-2Up-RegulationVascular Endothelial Growth Factor A1,2-DimethylhydrazineAngiopoietin-1Angiopoietin-2Angpt1 protein, ratDextran SulfateReceptor, TIE-2Vascular Endothelial Growth Factor Avascular endothelial growth factor A, ratAngiopoietin-1Angiopoietin-2Colorectal cancerTie-2Ulcerative colitisVascular endothelial growth factor

Identifiers

PMID25759532
PMCPMC4351214
OpenAlexW2016952168

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.