ReviewWorld journal of gastroenterology2015
Role of periostin and its antagonist PNDA-3 in gastric cancer metastasis.
Review in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Periostin: A matricellular protein with a multifaceted role in tumorigenesis (Review).International journal of molecular medicine · 2025Review
- Biological implications of decoding the extracellular matrix of vulva cancer.Oncology reports · 2025Review
- A Role for Periostin Pathological Variants and Their Interaction with HSP70-1a in Promoting Pancreatic Cancer Progression and Chemoresistance.International journal of molecular sciences · 2024Article
- The roles of periostin derived from cancer-associated fibroblasts in tumor progression and treatment response.Cancer metastasis reviews · 2024Review
- The role of periostin in cardiac fibrosis.Heart failure reviews · 2024Review
- Defining the timeline of periostin upregulation in cardiac fibrosis following acute myocardial infarction in mice.Scientific reports · 2022Article
- Periostin: biology and function in cancer.Cancer cell international · 2022Review
- Breast Cancer Aptamers: Current Sensing Targets, Available Aptamers, and Their Evaluation for Clinical Use in Diagnostics.Cancers · 2021Review
- Serum total periostin is an independent marker of overall survival in bone metastases of lung adenocarcinoma.Journal of bone oncology · 2021Article
- Prognostic significance of periostin in colorectal cancer.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2019Article
- Schwann cell-derived periostin promotes autoimmune peripheral polyneuropathy via macrophage recruitment.The Journal of clinical investigation · 2018Article
- Runx2-I is an Early Regulator of Epithelial-Mesenchymal Cell Transition in the Chick Embryo.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Article
- Cellular Delivery of RNA Nanoparticles.ACS combinatorial science · 2016Review
- Isoprenaline Induces Periostin Expression in Gastric Cancer.Yonsei medical journal · 2016Article
- Aptamers: A promising chemical antibody for cancer therapy.Oncotarget · 2016Review
- Matricellular proteins in drug delivery: Therapeutic targets, active agents, and therapeutic localization.Advanced drug delivery reviews · 2016Review
- Periostin on the road to nonalcoholic fatty liver disease.Endocrine · 2016Article
- Targeting ECM Disrupts Cancer Progression.Frontiers in oncology · 2015Review
- Protein profiling of plasma proteins in dairy cows with subclinical hypocalcaemia.Irish veterinary journalArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The extracellular matrix component periostin is a secreted protein that functions as both a cell attachment protein and an autocrine or paracrine factor that signals through the cell adhesion molecule integrins αvβ3 and αvβ5. Periostin participates in normal physiological activities such as cardiac development, but is also involved in pathophysiological processes in vascular diseases, wound repair, bone formation, and tumor development. It is of increasing interest in tumor biology because it is frequently overexpressed in a variety of epithelial carcinomas and is functionally involved in multiple steps of metastasis progression. These include the maintenance of stemness, niche formation, EMT, the survival of tumor cells, and angiogenesis, all of which are indispensable for gastric cancer metastasis. Periostin has been reported to activate the PI-3K/AKT, Wnt, and FAK-mediated signaling pathways to promote metastasis. Therefore, periostin represents a potentially promising candidate for the inhibition of metastasis. In this review article, we summarize recent advances in knowledge concerning periostin, its antagonist PNDA-3, and their influence on such key processes in cancer metastasis as maintenance of stemness, niche formation, epithelial-to-mesenchymal transition, tumor cell survival, and angiogenesis. In particular, we focus our attention on the role of periostin in gastric cancer metastasis, speculate as to the usefulness of periostin as a therapeutic and diagnostic target for gastric cancer metastasis, and consider potential avenues for future research.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.