ArticleJournal of assisted reproduction and genetics2015
Age-associated alterations in the micromechanical properties of chromosomes in the mammalian egg.
Article in Journal of assisted reproduction and genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed.
- What we could not have known: ovarian cycles, follicle development, and the signature of life.Molecular human reproduction · 2026Review
- The dynamics of DNA methylation, histone methylation and acetylation during oocyte aging in mammalian species and possible interventions to regulate them.Journal of assisted reproduction and genetics · 2025Review
- Article
- ZAR1/2-Regulated Epigenetic Modifications are Essential for Age-Associated Oocyte Quality Maintenance and Zygotic Activation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Hallmarks of female reproductive aging in physiologic aging mice.Nature aging · 2024Review
- Fibroinflammatory Signatures Increase with Age in the Human Ovary and Follicular Fluid.International journal of molecular sciences · 2021Article
- Article
- Inflammaging is associated with shifted macrophage ontogeny and polarization in the aging mouse ovary.Reproduction (Cambridge, England) · 2020Article
- Histologic analysis and lipid profiling reveal reproductive age-associated changes in peri-ovarian adipose tissue.Reproductive biology and endocrinology : RB&E · 2019Article
- The effects of biological aging on global DNA methylation, histone modification, and epigenetic modifiers in the mouse germinal vesicle stage oocyte.Animal reproduction · 2018Article
- Mitochondrial DNA content is associated with ploidy status, maternal age, and oocyte maturation methods in mouse blastocysts.Journal of assisted reproduction and genetics · 2017Article
- Article
- Reproductive age-associated fibrosis in the stroma of the mammalian ovary.Reproduction (Cambridge, England) · 2016Article
- Dependence of the structure and mechanics of metaphase chromosomes on oxidized cysteines.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2016Article
- Next Generation Sequencing-Based Comprehensive Chromosome Screening in Mouse Polar Bodies, Oocytes, and Embryos.Biology of reproduction · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
purposeThe incidence of aneuploidy in eggs from women of advanced reproductive age can exceed 60%, making the mammalian egg a unique model system to study the mechanisms of chromosome segregation errors.
methodsHere we applied a novel biophysical chromosome stretching approach to quantify mechanical stiffness of meiotic chromosomes in the mammalian egg and then documented how these properties changed in a mouse model of physiologic reproductive aging.
resultsWe found significant differences in chromosome micromechanics, and thus in higher order chromosome structure, coincident with advanced reproductive age, a time that is also unequivocally associated with an increase in egg aneuploidy.
conclusionsThese findings have important implications for both reproductive and cancer biology where aneuploidy plays a central role in aging related disease states.
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Registered trials
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