ArticleInvestigative ophthalmology & visual science2015
Comparison of Risk Factor Profiles for Primary Open-Angle Glaucoma Subtypes Defined by Pattern of Visual Field Loss: A Prospective Study.
Article in Investigative ophthalmology & visual science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Modifiable factors in the management of glaucoma: a systematic review of current evidence.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2017Pooled it
- PyVisualFields Version 2: From an R Wrapper to a Comprehensive Python Ecosystem for Visual Field and Glaucoma Research.Translational vision science & technology · 2026Article
- PyGlaucoMetrics: A Stacked Weight-Based Machine Learning Approach for Glaucoma Detection Using Visual Field Data.Medicina (Kaunas, Lithuania) · 2025Article
- Metabolomic Profiling of Open-Angle Glaucoma Etiologic Endotypes: Tohoku Multi-Omics Glaucoma Study.Investigative ophthalmology & visual science · 2024Article
- Use of Diagnostic Codes for Primary Open-Angle Glaucoma Polygenic Risk Score Construction in Electronic Health Record-Linked Biobanks.American journal of ophthalmology · 2024Article
- Article
- Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank.Nature communications · 2023Article
- Blood Pressure Measures and Incident Primary Open-Angle Glaucoma.Investigative ophthalmology & visual science · 2022Article
- Impact of Smoking on Visual Field Progression in a Long-term Clinical Follow-up.Ophthalmology · 2022Article
- Smoking Cessation May Reduce Risk of Visual Field Progression in Heavy Smokers.Journal of glaucoma · 2022Article
- Genetic Risk of Cardiovascular Disease Is Associated with Macular Ganglion Cell-Inner Plexiform Layer Thinning in an Early Glaucoma Cohort.Ophthalmology science · 2022Article
- Health screening program revealed risk factors associated with development and progression of papillomacular bundle defect.The EPMA journal · 2021Article
- Inter-Eye Association of Visual Field Defects in Glaucoma and Its Clinical Utility.Translational vision science & technology · 2020Article
- Low-carbohydrate-diet scores and the risk of primary open-angle glaucoma: data from three US cohorts.Eye (London, England) · 2020Article
- Prospective study of flavonoid intake and risk of primary open-angle glaucoma.Acta ophthalmologica · 2018Article
- Cigarette smoking and glaucoma in the United States population.Eye (London, England) · 2018Article
- Relationship Between Central Retinal Vessel Trunk Location and Visual Field Loss in Glaucoma.American journal of ophthalmology · 2017Article
- A Comprehensive Model of Colorectal Cancer by Risk Factor Status and Subsite Using Data From the Nurses' Health Study.American journal of epidemiology · 2017Article
- Ocular and Systemic Risk Factors of Different Morphologies of Scotoma in Patients with Normal-Tension Glaucoma.Journal of ophthalmology · 2017Article
- Thin minimal rim width at Bruch's membrane opening is associated with glaucomatous paracentral visual field loss.Clinical ophthalmology (Auckland, N.Z.) · 2017Article
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Abstract
purposeWe explored whether risk factor associations differed by primary open-angle glaucoma (POAG) subtypes defined by visual field (VF) loss pattern (i.e., paracentral or peripheral).
methodsWe included 77,157 women in the Nurses' Health Study (NHS) and 42,773 men in the Health Professionals Follow-up Study (HPFS 1986-2010), and incident medical record confirmed cases of paracentral (n = 440) and peripheral (n = 865) POAG subtypes. We evaluated African heritage, glaucoma family history, body mass index (BMI), mean arterial blood pressure, diabetes mellitus, physical activity, smoking, caffeine intake, and alcohol intake. We used competing risk Cox regression analyses modeling age as the metameter and stratified by age, cohort, and event type. We sequentially identified factors with the least significant differences in associations with POAG subtypes ("stepwise down" approach with P for heterogeneity [P-het] < 0.10 as threshold).
resultsBody mass index was more inversely associated with the POAG paracentral VF loss subtype than the peripheral VF loss subtype (per 10 kg/m2; hazard ratio [HR] = 0.67 [95% confidence interval (CI): 0.52, 0.86] versus HR = 0.93 [95% CI: 0.78, 1.10]; P-het = 0.03) as was smoking (per 10 pack-years; HR = 0.92 [95% CI: 0.87, 0.98] versus HR = 0.98 [95% CI: 0.94, 1.01]; P-het = 0.09). These findings were robust in sensitivity analyses using a "stepwise up" approach (identify factors that showed the most significant differences). Nonheterogeneous (P-het > 0.10) adverse associations with both POAG subtypes were observed with glaucoma family history, diabetes, African heritage, greater caffeine intake, and higher mean arterial pressure.
conclusionsThese data indicate that POAG with early paracentral VF loss has distinct as well as common determinants compared with POAG with peripheral VF loss.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.