Evidence map›Paper›PMID 25758627›Full record

Trial reportThe journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians2016

The effect of prenatal alcohol co-exposure on neonatal abstinence syndrome in infants born to mothers in opioid maintenance treatment.

Christine Kreitinger, Hilda Gutierrez, Ajna Hamidovic, Cheryl Schmitt, Preeyaporn Sarangarm, William F Rayburn, Lawrence Leeman, Ludmila N Bakhireva

Open access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Christine Kreitingera Department of Pharmacy Practice and Administrative Sciences , College of Pharmacy and.
Hilda Gutierreza Department of Pharmacy Practice and Administrative Sciences , College of Pharmacy and.
Ajna Hamidovica Department of Pharmacy Practice and Administrative Sciences , College of Pharmacy and.
Cheryl Schmitta Department of Pharmacy Practice and Administrative Sciences , College of Pharmacy and.
Preeyaporn Sarangarmc Department of Pharmacy , University of New Mexico Hospital , Albuquerque , NM , USA , and.
William F Rayburnd Department of Obstetrics and Gynecology , School of Medicine, University of New Mexico , Albuquerque , NM , USA.
Lawrence Leemanb Department of Family and Community Medicine , School of Medicine, University of New Mexico , Albuquerque , NM , USA .
Ludmila N Bakhirevaa Department of Pharmacy Practice and Administrative Sciences , College of Pharmacy and.
American Association of Colleges of Pharmacy · USUniversity of New Mexico · USUniversity of New Mexico Hospital · US

Funding

UNM HSC Clinical and Translational Science CenterUL1TR001449 · NCATS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CAMPEN, MATTHEW J, PANDHI, NANCY · 2015 to 2024
$36.9M
Understanding neurophysiological deficits in response inhibition in children with FASDP50AA022534 · NIAAA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Carlos Fernando Valenzuela · 2014 to 2026
$21.5M
University of New Mexico Clinical and Translational Science CenterUL1TR000041 · NCATS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI LARSON, RICHARD S · 2012 to 2014
$9.8M
The effect of the COVID-19 pandemic on alcohol use and psycho-somatic health in pregnant and postpartum women with intersecting vulnerabilities.R01AA021771 · NIAAA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BAKHIREVA, LUDMILA NICOLE · 2013 to 2022
$6.5M
Fetal ethanol-induced behavioral deficits: Mechanisms, diagnoses and interventionP20AA017068 · NIAAA · UNIVERSITY OF NEW MEXICO · PI SAVAGE, DANIEL D. · 2008 to 2012
$2.6M
Alcohol and Condom Use Resistance in Sexually Coercive/Violent MenR01AA017608 · NIAAA · UNIVERSITY OF WASHINGTON · PI DAVIS, KELLY CUE · 2009 to 2013
$2.1M
Utility of Phosphatidylethanol for Identification of Fetal Alcohol ExposureR03AA020170 · NIAAA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BAKHIREVA, LUDMILA NICOLE · 2010 to 2011
$74k
NCATS NIH HHS 8UL1TR00041NCATS NIH HHS UL1 TR000041NCATS NIH HHS UL1 TR001449NIAAA NIH HHS P20 AA017068NIAAA NIH HHS P50 AA022534NIAAA NIH HHS R01 AA017608NIAAA NIH HHS R01 AA021771NIAAA NIH HHS R03 AA020170NIAAA NIH HHS R03 AA020170 -01
6 · The paper itself

Abstract

objectiveThis study examined the effects of prenatal alcohol exposure (PAE) on the incidence and severity of neonatal abstinence syndrome (NAS). STUDY

designFor this pilot study, 70 pregnant women on opioid maintenance therapy (OMT) were recruited from a perinatal substance abuse clinic. Subjects were categorized into three study groups based on the timing of alcohol use during pregnancy as assessed by repeated self-reported measures and a comprehensive panel of ethanol biomarkers. NAS outcomes included: duration of hospital stay, the need for pharmacological treatment of NAS, newborn age at the initiation of NAS treatment, duration of treatment and cumulative methadone dose administered.

resultsThe study included a large proportion of ethnic minorities (81.4% Hispanic, 5.7% American Indian), women with less than a high school education (52.2%) and unplanned pregnancy (82.9%). In multivariate analysis, PAE was not associated with NAS outcomes; however, one newborn diagnosed with fetal alcohol syndrome (FAS) demonstrated much more severe NAS compared to other PAE infants. Interestingly, 3rd trimester PAE was associated with a higher prevalence of microcephaly (62.5%) compared to the PAE abstaining group (36.8%; p = 0.08).

conclusionIn this study, PAE was not associated with NAS severity; however, further examination in a larger study is needed.

Indexed as

AdultAlcohol DrinkingFemaleHumansIncidenceInfant, NewbornLength of StayMethadoneNeonatal Abstinence SyndromeOpiate Substitution TreatmentOpioid-Related DisordersPregnancyPregnancy ComplicationsPrenatal Exposure Delayed EffectsSeverity of Illness IndexYoung AdultMethadoneAlcoholmethadoneneonatal abstinence syndromeopioidspregnancy

Identifiers

PMID25758627
PMCPMC4679632
OpenAlexW1981196416

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.