ArticleJournal of the American Heart Association2015
Impaired right ventricular hemodynamics indicate preclinical pulmonary hypertension in patients with metabolic syndrome.
Article in Journal of the American Heart Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- Kidney Dysfunction, Hepatic Impairment, and Lipid Metabolism Abnormalities in Patients with Precapillary Pulmonary Hypertension.Diagnostics (Basel, Switzerland) · 2024Article
- Endothelial Senescence: A New Age in Pulmonary Hypertension.Circulation research · 2022Review
- Emerging therapies: The potential roles SGLT2 inhibitors, GLP1 agonists, and ARNI therapy for ARNI pulmonary hypertension.Pulmonary circulation · 2022Review
- Effects of Sodium-Glucose Linked Transporter 2 Inhibition With Ertugliflozin on Mitochondrial Function, Energetics, and Metabolic Gene Expression in the Presence and Absence of Diabetes Mellitus in Mice.Journal of the American Heart Association · 2021Article
- Cine MRI characterizes HFpEF and HFrEF in post-capillary pulmonary hypertension.European journal of radiology · 2021Article
- Frataxin deficiency promotes endothelial senescence in pulmonary hypertension.The Journal of clinical investigation · 2021Article
- Molecular mechanisms of right ventricular dysfunction in pulmonary arterial hypertension: focus on the coronary vasculature, sex hormones, and glucose/lipid metabolism.Cardiovascular diagnosis and therapy · 2020Review
- Impact of cardiologist intervention on guideline-directed use of statin therapy.World journal of cardiology · 2020Article
- Obesity Is Associated With Pulmonary Hypertension and Modifies Outcomes.Journal of the American Heart Association · 2020Observational
- Pulmonary Artery Acceleration Time in Young Adulthood and Cardiovascular Outcomes Later in Life: The Coronary Artery Risk Development in Young Adults Study.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2020Article
- Inhibition of microRNA-146a attenuated heart failure in myocardial infarction rats.Bioscience reports · 2019Article
- Article
- Mitochondrial metabolism in pulmonary hypertension: beyond mountains there are mountains.The Journal of clinical investigation · 2018Review
- Diabetes Mellitus Associates with Increased Right Ventricular Afterload and Remodeling in Pulmonary Arterial Hypertension.The American journal of medicine · 2018Article
- Pulmonary hypertension and cardiac hypertrophy in children recipients of orthotopic living related liver transplantation.Journal of advanced research · 2017Article
- Echocardiographic Pulmonary Artery Systolic Pressure in the Coronary Artery Risk Development in Young Adults (CARDIA) Study: Associations With Race and Metabolic Dysregulation.Journal of the American Heart Association · 2017Observational
- Impact of Body Mass Index >50 on Cardiac Structural and Functional Characteristics and Surgical Outcomes After Bariatric Surgery.Obesity surgery · 2016Article
- Role of oxidized lipids in pulmonary arterial hypertension.Pulmonary circulation · 2016Review
- Challenges and opportunities in treating inflammation associated with pulmonary hypertension.Expert review of cardiovascular therapy · 2016Review
- Correlation between heart rate variability and pulmonary function adjusted by confounding factors in healthy adults.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2016Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundMetabolic disease can lead to intrinsic pulmonary hypertension in experimental models. The contributions of metabolic syndrome (MetS) and obesity to pulmonary hypertension and right ventricular dysfunction in humans remain unclear. We investigated the association of MetS and obesity with right ventricular structure and function in patients without cardiovascular disease. METHODS AND
resultsA total of 156 patients with MetS (mean age 44 years, 71% women, mean body mass index 40 kg/m(2)), 45 similarly obese persons without MetS, and 45 nonobese controls underwent echocardiography, including pulsed wave Doppler measurement of pulmonary artery acceleration time (PAAT) and ejection time. Pulmonary artery systolic pressure was estimated from PAAT using validated equations. MetS was associated with lower tricuspid valve e' (right ventricular diastolic function parameter), shorter PAAT, shorter ejection time, and larger pulmonary artery diameter compared with controls (P<0.05 for all). Estimated pulmonary artery systolic pressure based on PAAT was 42±12 mm Hg in participants with MetS compared with 32±9 and 32±10 mm Hg in obese and nonobese controls (P for ANOVA <0.0001). After adjustment for age, sex, hypertension, diabetes, body mass index, and triglycerides, MetS remained associated with a 20-ms-shorter PAAT (β=-20.4, SE=6.5, P=0.002 versus obese). This association persisted after accounting for left ventricular structure and function and after exclusion of participants with obstructive sleep apnea.
conclusionsMetS is associated with abnormal right ventricular and pulmonary artery hemodynamics, as shown by shorter PAAT and subclinical right ventricular diastolic dysfunction. Estimated pulmonary artery systolic pressures are higher in MetS and preclinical metabolic heart disease and raise the possibility that pulmonary hypertension contributes to the pathophysiology of metabolic heart disease.
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