SynthesisClinical orthopaedics and related research2015
Do Complication Rates Differ by Gender After Metal-on-metal Hip Resurfacing Arthroplasty? A Systematic Review.
Synthesis in Clinical orthopaedics and related research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Women Have Tendons… and Tendinopathy: Gender Bias is a "Gender Void" in Sports Medicine with a Lack of Women Data on Patellar Tendinopathy-A Systematic Review.Sports medicine - open · 2022Pooled it
- The anatomical location of cystic pseudotumors and muscle atrophy in metal-on-metal resurfacing hip arthroplasty is related to the surgical approach used for implantation. A subgroup analyses of a randomized controlled trial.Archives of orthopaedic and trauma surgery · 2023Trial
- Bone-Sparing Hip Arthroplasty in Young and Active Patients: A Narrative Review.Journal of clinical medicine · 2026Review
- Metal-on-metal hip implants: Revisiting degradation product chemistry and molecular mechanisms of ARMD.Biomaterials and biosystems · 2026Review
- Observational study exploring the association between sexes and perioperative morbidities after aseptic hip revision arthroplasty.BMC musculoskeletal disorders · 2026Observational
- Inclusion and reporting by age, sex, and ethnicity in clinical studies of high-risk medical devices approved in the European Union.European heart journal. Quality of care & clinical outcomes · 2025Article
- Long-term outcomes of small head metal-on-metal compared to ceramic-on-polyethylene primary total hip arthroplasty: a registry-based cohort study.International orthopaedics · 2025Article
- What is the long-term survivorship, complication profile, and patient reported outcomes after Birmingham hip resurfacing?Journal of orthopaedics · 2024Review
- Towards the First Generation of Biomimetic Fixation for Resurfacing Arthroplasty Endoprostheses.Biomimetics (Basel, Switzerland) · 2024Review
- Careful patient selection together with optimal implant positioning may reduce but does not eliminate the risk of elevated serum cobalt and chrome levels following metal-on-metal hip resurfacing.Hip international : the journal of clinical and experimental research on hip pathology and therapy · 2023Article
- Same-gender differences in perioperative complications and transfusion management for lower limb arthroplasty.BMC musculoskeletal disorders · 2023Article
- Comparisons of in-hospital complications between total hip arthroplasty and hip resurfacing arthroplasty.BMC musculoskeletal disorders · 2023Article
- Challenges and solutions to advancing health equity with medical devices.Nature biotechnology · 2023Article
- Sex and Gender-Related Differences in the Outcome of Total Hip Arthroplasty: A Current Concepts Review.Medicina (Kaunas, Lithuania) · 2022Review
- Minimum 10-Year Results of Modular Metal-On-Metal Total Hip Arthroplasty.Journal of clinical medicine · 2022Article
- Predictive factors affecting long-term survivorship of ASR metal-on-metal total hip arthroplasty.SICOT-J · 2021Article
- Gender-Specific Response in Pain and Function to Biologic Treatment of Knee Osteoarthritis: A Gender-Bias-Mitigated, Observational, Intention-to-Treat Study at Two Years.Stem cells international · 2021Article
- Hip resurfacing arthroplasty for osteonecrosis of the femoral head: Implant-specific outcomes and risk factors for failure.Journal of orthopaedic translation · 2020Article
- Development of an Integrated Platform Using Multidisciplinary Real-World Data to Facilitate Biomarker Discovery for Medical Products.Clinical and translational science · 2020Article
- Diagnosis and management of implant debris-associated inflammation.Expert review of medical devices · 2020Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough metal-on-metal (MoM) bearing surfaces provide low rates of volumetric wear and increased stability, evidence suggests that certain MoM hip arthroplasties have high rates of complication and failure. Some evidence indicates that women have higher rates of failure compared with men; however, the orthopaedic literature as a whole has poorly reported such complications stratified by gender. QUESTIONS/PURPOSES: This systematic review aimed to: (1) compare the rate of adverse local tissue reaction (ALTR); (2) dislocation; (3) aseptic loosening; and (4) revision between men and women undergoing primary MoM hip resurfacing arthroplasty (HRA).
methodsSystematic MEDLINE and EMBASE searches identified all level I to III articles published in peer-reviewed journals, reporting on the outcomes of interest, for MoM HRA. Articles were limited to those with 2-year followup that reported outcomes by gender. Ten articles met inclusion criteria. Study quality was evaluated using the Modified Coleman Methodology Score; the overall quality was poor. Heterogeneity and bias were analyzed using a Mantel-Haenszel statistical method.
resultsWomen demonstrated an increased odds of developing ALTR (odds ratio [OR], 5.70 [2.71-11.98]; p<0.001), dislocation (OR, 3.04 [1.2-7.5], p=0.02), aseptic loosening (OR, 3.18 [2.21-4.58], p<0.001), and revision (OR, 2.50 [2.25-2.78], p<0.001) after primary MoM HRA.
conclusionsA systematic review of the currently available literature reveals a higher rate of complications (ALTR, dislocation, aseptic loosening, and revision) after MoM HRA in women compared with men. Although femoral head size has been frequently implicated as a prime factor in the higher rate of complication in women, further research is necessary to specifically probe this relationship. Retrospective studies of data available (eg, registry data) should be undertaken, and moving forward studies should report outcomes by gender (particularly complications). LEVEL OF EVIDENCE: Level III, therapeutic study.
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