ArticleMicrobial ecology in health and disease2015
Towards large-cohort comparative studies to define the factors influencing the gut microbial community structure of ASD patients.
Article in Microbial ecology in health and disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Natamycin in Food and Ophthalmology: Knowledge Gaps and Emerging Insights from Zebrafish Models.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Article
- Association between prenatal antimicrobial use and offspring attention deficit hyperactivity disorder.PloS one · 2023Article
- The Impact of Gut Microbiota-Derived Metabolites in Autism Spectrum Disorders.International journal of molecular sciences · 2021Review
- Influence of immunomodulatory drugs on the gut microbiota.Translational research : the journal of laboratory and clinical medicine · 2021Review
- The association between obesity and weight loss after bariatric surgery on the vaginal microbiota.Microbiome · 2021Article
- The Gut Microbiome in Autism: Study-Site Effects and Longitudinal Analysis of Behavior Change.mSystems · 2021Article
- Article
- CCMP: software-as-a-service approach for fully-automated microbiome profiling.Journal of biomedical informatics: X · 2019Article
- Current understanding of the human microbiome.Nature medicine · 2018Review
- Does the vaginal microbiota play a role in the development of cervical cancer?Translational research : the journal of laboratory and clinical medicine · 2017Review
- Introduction.Microbial ecology in health and disease · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Differences in the gut microbiota have been reported between individuals with autism spectrum disorders (ASD) and neurotypical controls, although direct evidence that changes in the microbiome contribute to causing ASD has been scarce to date. Here we summarize some considerations of experimental design that can help untangle causality in this complex system. In particular, large cross-sectional studies that can factor out important variables such as diet, prospective longitudinal studies that remove some of the influence of interpersonal variation in the microbiome (which is generally high, especially in children), and studies transferring microbial communities into germ-free mice may be especially useful. Controlling for the effects of technical variables, which have complicated efforts to combine existing studies, is critical when biological effect sizes are small. Large citizen-science studies with thousands of participants such as the American Gut Project have been effective at uncovering subtle microbiome effects in self-collected samples and with self-reported diet and behavior data, and may provide a useful complement to other types of traditionally funded and conducted studies in the case of ASD, especially in the hypothesis generation phase.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.