ArticleJournal of neurotrauma2015
Abnormal White Matter Blood-Oxygen-Level-Dependent Signals in Chronic Mild Traumatic Brain Injury.
Article in Journal of neurotrauma, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Diffusion-Weighted Imaging in Mild Traumatic Brain Injury: A Systematic Review of the Literature.Neuropsychology review · 2023Pooled it
- Eye movements and ocular biomarkers in mild traumatic brain injury: from oculomotor pathophysiology to diagnosis and prognosis.Journal of neurology · 2026Review
- Eye-Tracking Technologies for Cognitive Assessment After Acquired Brain Injury: Systematic Review.JMIR rehabilitation and assistive technologies · 2026Review
- Whole-brain, gray, and white matter time-locked functional signal changes with simple tasks and model-free analysis.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Volumetric MRI Findings in Mild Traumatic Brain Injury (mTBI) and Neuropsychological Outcome.Neuropsychology review · 2023Review
- A window into eye movement dysfunction following mTBI: A scoping review of magnetic resonance imaging and eye tracking findings.Brain and behavior · 2022Article
- Eye Tracking Parameters Correlate with the Level of Cerebral Oxygen Saturation in Mild Traumatic Brain Injury: A Preliminary Study.Advances in experimental medicine and biology · 2022Article
- Eye Movements in Mild Traumatic Brain Injury: Ocular Biomarkers.Journal of eye movement research · 2022Article
- Neuropathological Mechanisms of Mild Traumatic Brain Injury: A Perspective From Multimodal Magnetic Resonance Imaging.Frontiers in neuroscience · 2022Review
- Noninvasive magnetic resonance imaging techniques in mild traumatic brain injury research and diagnosis.Human brain mapping · 2021Review
- Article
- Functional Magnetic Resonance Imaging and Oculomotor Dysfunction in Mild Traumatic Brain Injury.Journal of neurotrauma · 2019Article
- Activations in gray and white matter are modulated by uni-manual responses during within and inter-hemispheric transfer: effects of response hand and right-handedness.Brain imaging and behavior · 2018Article
- Traumatic Brain Injury and Alzheimer's Disease: The Cerebrovascular Link.EBioMedicine · 2018Review
- Association of Visual Tracking Metrics With Post-concussion Symptomatology.Frontiers in neurology · 2018Article
- Feasibility of using normobaric hypoxic stress in mTBI research.Concussion (London, England) · 2017Review
- Effects of Tissue-Specific Functional Magnetic Resonance Imaging Signal Regression on Resting-State Functional Connectivity.Brain connectivity · 2017Article
- Reliability of the depth-dependent high-resolution BOLD hemodynamic response in human visual cortex and vicinity.Magnetic resonance imaging · 2017Article
- Functional connectivity and activity of white matter in somatosensory pathways under tactile stimulations.NeuroImage · 2017Article
- Pathological vascular and inflammatory biomarkers of acute- and chronic-phase traumatic brain injury.Concussion (London, England) · 2017Review
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
Concussion, or mild traumatic brain injury (mTBI), can cause persistent behavioral symptoms and cognitive impairment, but it is unclear if this condition is associated with detectable structural or functional brain changes. At two sites, chronic mTBI human subjects with persistent post-concussive symptoms (three months to five years after injury) and age- and education-matched healthy human control subjects underwent extensive neuropsychological and visual tracking eye movement tests. At one site, patients and controls also performed the visual tracking tasks while blood-oxygen-level-dependent (BOLD) signals were measured with functional magnetic resonance imaging. Although neither neuropsychological nor visual tracking measures distinguished patients from controls at the level of individual subjects, abnormal BOLD signals were reliably detected in patients. The most consistent changes were localized in white matter regions: anterior internal capsule and superior longitudinal fasciculus. In contrast, BOLD signals were normal in cortical regions, such as the frontal eye field and intraparietal sulcus, that mediate oculomotor and attention functions necessary for visual tracking. The abnormal BOLD signals accurately differentiated chronic mTBI patients from healthy controls at the single-subject level, although they did not correlate with symptoms or neuropsychological performance. We conclude that subjects with persistent post-concussive symptoms can be identified years after their TBI using fMRI and an eye movement task despite showing normal structural MRI and DTI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.