ArticleMolecular biology and evolution2015
Adaptive Evolution as a Predictor of Species-Specific Innate Immune Response.
Article in Molecular biology and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Laboratory and physiological aspects of substitute metazoan models for in vivo pharmacotoxicological analysis.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Article
- Complex patterns shape immune genes diversity during invasion of common raccoon in Europe - Selection in action despite genetic drift.Evolutionary applications · 2023Article
- Selection Balancing at Innate Immune Genes: Adaptive Polymorphism Maintenance in Toll-Like Receptors.Molecular biology and evolution · 2022Review
- A network view of human immune system and virus-human interaction.Frontiers in immunology · 2022Article
- Adaptive Evolution in TRIF Leads to Discordance between Human and Mouse Innate Immune Signaling.Genome biology and evolution · 2021Article
- An Analysis of Methylome Evolution in Primates.Molecular biology and evolution · 2021Article
- Neuroprotection and Axonal Regeneration Induced by Bone Marrow Mesenchymal Stromal Cells Depend on the Type of Transplant.Frontiers in cell and developmental biology · 2021Article
- Integrated structural and evolutionary analysis reveals common mechanisms underlying adaptive evolution in mammals.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Exploiting species specificity to understand the tropism of a human-specific toxin.Science advances · 2020Article
- Genomic Signatures After Five Generations of Intensive Selective Breeding: Runs of Homozygosity and Genetic Diversity in Representative Domestic and Wild Populations of Turbot (Frontiers in genetics · 2020Article
- Origin and development of oligoadenylate synthetase immune system.BMC evolutionary biology · 2018Article
- Host species adaptation of TLR5 signalling and flagellin recognition.Scientific reports · 2017Article
- PosiGene: automated and easy-to-use pipeline for genome-wide detection of positively selected genes.Nucleic acids research · 2017Article
- Evolution of toll-like receptors in the context of terrestrial ungulates and cetaceans diversification.BMC evolutionary biology · 2017Article
- Article
- Selective Landscapes in newt Immune Genes Inferred from Patterns of Nucleotide Variation.Genome biology and evolution · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been proposed that positive selection may be associated with protein functional change. For example, human and macaque have different outcomes to HIV infection and it has been shown that residues under positive selection in the macaque TRIM5α receptor locate to the region known to influence species-specific response to HIV. In general, however, the relationship between sequence and function has proven difficult to fully elucidate, and it is the role of large-scale studies to help bridge this gap in our understanding by revealing major patterns in the data that correlate genotype with function or phenotype. In this study, we investigate the level of species-specific positive selection in innate immune genes from human and mouse. In total, we analyzed 456 innate immune genes using codon-based models of evolution, comparing human, mouse, and 19 other vertebrate species to identify putative species-specific positive selection. Then we used population genomic data from the recently completed Neanderthal genome project, the 1000 human genomes project, and the 17 laboratory mouse genomes project to determine whether the residues that were putatively positively selected are fixed or variable in these populations. We find evidence of species-specific positive selection on both the human and the mouse branches and we show that the classes of genes under positive selection cluster by function and by interaction. Data from this study provide us with targets to test the relationship between positive selection and protein function and ultimately to test the relationship between positive selection and discordant phenotypes.
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