Evidence map›Paper›PMID 25757811›Full record

ReviewJournal of minimally invasive gynecology

Circulating Micro-RNAs as Diagnostic Biomarkers for Endometriosis: Privation and Promise.

Warren B Nothnick, Ayman Al-Hendy, John R Lue

Open access · greenAbstract readReview
In one paragraph

Review in Journal of minimally invasive gynecology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Liquid Biopsy in Endometriosis: A Systematic Review.International journal of molecular sciences · 2023
    Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Prognostic Significance ofCancer management and research · 2021
    Article
  9. Article
  10. Non-Coding RNAs in Endometrial Physiopathology.International journal of molecular sciences · 2018
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Warren B NothnickDepartment of Molecular and Integrative Physiology, Center for Reproductive Sciences, Institute of Reproductive Health and Regenerative Medicine, University of Kansas Medical Center, Kansas City, Kansas. Electronic address: wnothnic@kumc.edu.
Ayman Al-HendyDepartment of Obstetrics and Gynecology, Georgia Regents University, Medical College of Georgia, Augusta, Georgia.
John R LueDepartment of Obstetrics and Gynecology, Georgia Regents University, Medical College of Georgia, Augusta, Georgia.
Augusta University · USUniversity of Kansas Medical Center · US

Funding

The Role of miR-451 in Endometriosis Pathophysiology and TreatmentR01HD069043 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI NOTHNICK, WARREN B · 2012 to 2016
$1.7M
NICHD NIH HHS R01 HD069043NICHD NIH HHS R01HD069043
6 · The paper itself

Abstract

Endometriosis represents a major medical concern in women of reproductive age. One of the remaining major hurdles for successful treatment of endometriosis is the limitation of the process of timely disease diagnosis. A simple blood test for endometriosis-specific biomarkers would offer a more timely accurate diagnosis for the disease, thus allowing for earlier treatment intervention. Although there have been considerable efforts to identify such biomarkers, no clear choice for such noninvasive diagnostic tools has been identified. Micro-RNAs are small noncoding RNAs that have been evaluated intensively as biomarkers for several diseases, and they may hold promise for a diagnosis of endometriosis. In this review, we highlight the need for noninvasive testing for endometriosis, discuss the potential use of micro-RNAs as diagnostic tools for this disease, and consider potential limitations in the use of these small RNA molecules as diagnostic markers for endometriosis.

Indexed as

BiomarkersEndometriosisFemaleGene Expression ProfilingHumansIntercellular Signaling Peptides and ProteinsMicroRNAsSensitivity and SpecificityBiomarkersIntercellular Signaling Peptides and ProteinsMicroRNAsDiagnostic biomarkerEndometriosismicroRNA

Identifiers

PMID25757811
PMCPMC4489990
OpenAlexW2081162415

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.