ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2015
Angiotensin-(1-7) protects against the development of aneurysmal subarachnoid hemorrhage in mice.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 40 citations in OpenAlex.
- Roles of Sirtuin-1 in the Prevention of Intracranial Aneurysm Rupture in Mice.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Impact of premorbid hypertension and renin-angiotensin-aldosterone system inhibitors on the severity of aneurysmal subarachnoid haemorrhage: a multicentre study.Stroke and vascular neurology · 2025Observational
- Angiotensin Inhibition Reduces the Risk of Subarachnoid Hemorrhage in Patients With Hypertension.Stroke (Hoboken, N.J.) · 2025Article
- Review
- Vitamin D deficiency promotes intracranial aneurysm rupture.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Pharmacological Inhibition of Epidermal Growth Factor Receptor Prevents Intracranial Aneurysm Rupture by Reducing Endoplasmic Reticulum Stress.Hypertension (Dallas, Tex. : 1979) · 2024Article
- PI3K/Akt/Nrf2 mediated cellular signaling and virus-host interactions: latest updates on the potential therapeutic management of SARS-CoV-2 infection.Frontiers in molecular biosciences · 2023Review
- Attenuation of Smooth Muscle Cell Phenotypic Switching by Angiotensin 1-7 Protects against Thoracic Aortic Aneurysm.International journal of molecular sciences · 2022Article
- Endogenous animal models of intracranial aneurysm development: a review.Neurosurgical review · 2021Review
- Article
- Neutrophil Extracellular Traps Promote the Development of Intracranial Aneurysm Rupture.Hypertension (Dallas, Tex. : 1979) · 2021Article
- COVID-19 cellular pathogenesis in brief.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2021Article
- Article
- Review
- AVE0991, a nonpeptide angiotensin-(1-7) mimic, inhibits angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E knockout mice.Journal of molecular medicine (Berlin, Germany) · 2020Article
- Angiotensin-(1-7) mitigated angiotensin II-induced abdominal aortic aneurysms in apolipoprotein E-knockout mice.British journal of pharmacology · 2020Article
- Recent Research Advances in Renin-Angiotensin-Aldosterone System Receptors.Current hypertension reports · 2020Review
- Preclinical Intracranial Aneurysm Models: A Systematic Review.Brain sciences · 2020Review
- TLR4 (Toll-Like Receptor 4) Mediates the Development of Intracranial Aneurysm Rupture.Hypertension (Dallas, Tex. : 1979) · 2020Article
- Angiotensin-(1-7): Translational Avenues in Cardiovascular Control.American journal of hypertension · 2019Review
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
Angiotensin-(1-7) (Ang-(1-7)) can regulate vascular inflammation and remodeling, which are processes that have important roles in the pathophysiology of intracranial aneurysms. In this study, we assessed the effects of Ang-(1-7) in the development of intracranial aneurysm rupture using a mouse model of intracranial aneurysms in which aneurysmal rupture (i.e., aneurysmal subarachnoid hemorrhage) occurs spontaneously and causes neurologic symptoms. Treatment with Ang-(1-7) (0.5 mg/kg/day), Mas receptor antagonist (A779 0.5 mg/kg/day or 2.5 mg/kg/day), or angiotensin II type 2 receptor (AT2R) antagonist (PD 123319, 10 mg/kg/day) was started 6 days after aneurysm induction and continued for 2 weeks. Angiotensin-(1-7) significantly reduced the rupture rate of intracranial aneurysms without affecting the overall incidence of aneurysms. The protective effect of Ang-(1-7) was blocked by the AT2R antagonist, but not by the Mas receptor antagonist. In AT2R knockout mice, the protective effect of Ang-(1-7) was absent. While AT2R mRNA was abundantly expressed in the cerebral arteries and aneurysms, Mas receptor mRNA expression was very scarce in these tissues. Angiotensin-(1-7) reduced the expression of tumor necrosis factor-α and interleukin-1β in cerebral arteries. These findings indicate that Ang-(1-7) can protect against the development of aneurysmal rupture in an AT2R-dependent manner.
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