ArticleBMC genomics2015
A search for protein biomarkers links olfactory signal transduction to social immunity.
Article in BMC genomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Functional Analysis of PxylPBP2 Responding to Repellent Activity of Natural Pyrazine Against Diamondback Moth.Insects · 2026Article
- Biological costs and benefits of selective breeding for disease resistance using marker-assisted or field-based selective breeding in honey bees (Apis mellifera).Journal of economic entomology · 2026Article
- Integrative Omics and AI-Driven Systems Biology: Multilayer Networks DecodingJournal of proteome research · 2025Review
- An odorant-binding protein functions in fire ant social immunity interfacing with innate immunity.Open biology · 2025Article
- Sequence-Based Multi Ancestry Association Study Reveals the Polygenic Architecture of Varroa destructor Resistance in the Honeybee Apis mellifera.Molecular ecology · 2025Article
- Honey bees bred for Varroa sensitive hygiene trait demonstrate resistance to chalkbrood disease.PloS one · 2025Article
- Expression of Molecular Markers of Resilience againstInsects · 2023Article
- Roles of insect odorant binding proteins in communication and xenobiotic adaptation.Frontiers in insect science · 2023Review
- Combined transcriptome and metabolite profiling analyses provide insights into the chronic toxicity of carbaryl and acetamiprid to Apis mellifera larvae.Scientific reports · 2022Article
- Review
- Genome-wide patterns of differentiation within and among U.S. commercial honey bee stocks.BMC genomics · 2020Article
- Individual-Level Comparisons of Honey Bee (Hymenoptera: Apoidea) Hygienic Behavior Towards Brood Infested withInsects · 2020Article
- Increased immunocompetence and network centrality of allogroomer workers suggest a link between individual and social immunity in honeybees.Scientific reports · 2020Article
- Mating precedes selective immune priming which is maintained throughout bumblebee queen diapause.BMC genomics · 2019Article
- The Emerging Proteomic Research Facilitates in-Depth Understanding of the Biology of Honeybees.International journal of molecular sciences · 2019Review
- Review
- Integrative Genomics Reveals the Genetics and Evolution of the Honey Bee's Social Immune System.Genome biology and evolution · 2019Article
- Managing the risks and rewards of death in eusocial insects.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- A death pheromone, oleic acid, triggers hygienic behavior in honey bees (Apis mellifera L.).Scientific reports · 2018Article
- Antennal Protein Profile in Honeybees: Caste and Task Matter More Than Age.Frontiers in physiology · 2018Article
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Authors and funding
13 authors.
Funding
Abstract
backgroundThe Western honey bee (Apis mellifera L.) is a critical component of human agriculture through its pollination activities. For years, beekeepers have controlled deadly pathogens such as Paenibacillus larvae, Nosema spp. and Varroa destructor with antibiotics and pesticides but widespread chemical resistance is appearing and most beekeepers would prefer to eliminate or reduce the use of in-hive chemicals. While such treatments are likely to still be needed, an alternate management strategy is to identify and select bees with heritable traits that allow them to resist mites and diseases. Breeding such bees is difficult as the tests involved to identify disease-resistance are complicated, time-consuming, expensive and can misidentify desirable genotypes. Additionally, we do not yet fully understand the mechanisms behind social immunity. Here we have set out to discover the molecular mechanism behind hygienic behavior (HB), a trait known to confer disease resistance in bees.
resultsAfter confirming that HB could be selectively bred for, we correlated measurements of this behavior with protein expression over a period of three years, at two geographically distinct sites, using several hundred bee colonies. By correlating the expression patterns of individual proteins with HB scores, we identified seven putative biomarkers of HB that survived stringent control for multiple hypothesis testing. Intriguingly, these proteins were all involved in semiochemical sensing (odorant binding proteins), nerve signal transmission or signal decay, indicative of the series of events required to respond to an olfactory signal from dead or diseased larvae. We then used recombinant versions of two odorant-binding proteins to identify the classes of ligands that these proteins might be helping bees detect.
conclusionsOur data suggest that neurosensory detection of odors emitted by dead or diseased larvae is the likely mechanism behind a complex and important social immunity behavior that allows bees to co-exist with pathogens.
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