ArticleThe journal of physiological sciences : JPS2015
Regulation of intracellular Zn homeostasis in two intestinal epithelial cell models at various maturation time points.
Article in The journal of physiological sciences : JPS, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 20 citations in OpenAlex.
- Comparison of apical and basolateral Cu treatment for iron-related gene regulation during deferoxamine induced iron deficiency.Genes & nutrition · 2022Article
- A Guide to Human Zinc Absorption: General Overview and Recent Advances of In Vitro Intestinal Models.Nutrients · 2020Review
- A change in the zinc ion concentration reflects the maturation of insulin-producing cells generated from adipose-derived mesenchymal stem cells.Scientific reports · 2019Article
- Silicon dioxide nanoparticle exposure affects small intestine function in an in vitro model.Nanotoxicology · 2018Article
- The novel ZIP4 regulation and its role in ovarian cancer.Oncotarget · 2017Article
- Physiological roles of zinc transporters: molecular and genetic importance in zinc homeostasis.The journal of physiological sciences : JPS · 2017Review
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
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Abstract
After weaning, piglets are often fed diets supplemented with high concentrations of zinc (Zn) to decrease post-weaning diarrhea. The aim of this study was to elucidate the regulation of Zn homeostasis within intestinal epithelial cells during excessive Zn exposure. High Zn concentrations elevated the intracellular Zn level in IPEC-J2 and Caco-2 cells which was influenced by differentiation status and time of exposure. With increasing Zn concentrations, mRNA and protein levels of metallothionein (MT) and zinc transporter 1 (ZnT1) were upregulated, whereas zinc transporter 4 (ZIP4) expression was downregulated. Metal-regulatory transcription factor-1 (MTF1) mRNA expression was upregulated at high Zn concentrations in IPEC-J2 cells, which corresponded to higher intracellular Zn concentrations. Based on these results, we suggest that intestinal epithelial cells adapt the expression of these genes to the amount of extracellular Zn available in order to maintain Zn homeostasis. Cell line-dependent differences in the regulation of Zn homeostasis were detected.
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