ArticleDigestive diseases and sciences2015
Vitamin D Status Is Associated with Intestinal Inflammation as Measured by Fecal Calprotectin in Crohn's Disease in Clinical Remission.
Article in Digestive diseases and sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 57 citations in OpenAlex.
- Effect of Vitamin D Supplementation on Faecal Microbiota: A Randomised Clinical Trial.Nutrients · 2019Trial
- Vitamin D Supplementation Modulates T Cell-Mediated Immunity in Humans: Results from a Randomized Control Trial.The Journal of clinical endocrinology and metabolism · 2016Trial
- Importance of vitamin D in gastrointestinal health and disease.Frontiers in nutrition · 2026Review
- The role of vitamin D deficiency and modifiable risk factors in patients with Crohn's disease.Frontiers in immunology · 2025Article
- Joint Detection of Serum Vitamin D, Body Mass Index, and Tumor Necrosis Factor Alpha for the Diagnosis of Crohn's Disease.Current medical science · 2023Article
- Vitamin D and colorectal cancer: Chemopreventive perspectives through the gut microbiota and the immune system.BioFactors (Oxford, England) · 2022Review
- Emerging Roles of Vitamin D-Induced Antimicrobial Peptides in Antiviral Innate Immunity.Nutrients · 2022Review
- Vitamin DFrontiers in nutrition · 2022Article
- Hypocholesterolemia and Inflammatory Biomarkers Act as Predictors of Severe Vitamin D Deficiency in Patients With Crohn's Disease: A Clinical Analysis of 862 Patients in China.Frontiers in nutrition · 2022Article
- Vitamin D: Dosing, levels, form, and route of administration: Does one approach fit all?Reviews in endocrine & metabolic disorders · 2021Review
- Diet in Intestinal Fibrosis: A Double-Edged Sword.Nutrients · 2021Review
- Vitamin D Receptor Gene Single Nucleotide Polymorphisms and Association With Vitamin D Levels and Endoscopic Disease Activity in Inflammatory Bowel Disease Patients: A Pilot Study.Inflammatory bowel diseases · 2021Article
- Sarcopenia and Vitamin D Deficiency in Patients with Crohn's Disease: Pathological Conditions That Should Be Linked Together.Nutrients · 2021Review
- Dietary Derived Micronutrients Modulate Immune Responses Through Innate Lymphoid Cells.Frontiers in immunology · 2021Review
- Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions.Endocrine reviews · 2019Review
- Influence of Vitamin D Deficiency on Inflammatory Markers and Clinical Disease Activity in IBD Patients.Nutrients · 2019Article
- The effect of vitamin D administration on inflammatory markers in patients with inflammatory bowel disease.Intestinal research · 2019Article
- The intestinal vitamin D receptor in inflammatory bowel disease: inverse correlation with inflammation but no relationship with circulating vitamin D status.Therapeutic advances in gastroenterology · 2019Article
- Vitamin D deficiency is associated with disease activity in patients with Crohn's disease.Intestinal research · 2019Article
- Seasonal variability of vitamin D status in patients with inflammatory bowel disease - A retrospective cohort study.PloS one · 2019Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVitamin D, as potential immune modulator, has been implicated as an environmental risk factor for Crohn's disease (CD). Vitamin D status may be associated with disease risk, severity, activity, and progression. While associations between circulating 25OHD and markers of disease activity and inflammation in CD have been reported, the results are inconsistent.
aimTo determine the association between vitamin D status and markers of disease activity and inflammation in CD.
methodsOne hundred and nineteen CD patients' active and inactive diseases were enrolled in the cross-sectional study. Subject demographics and clinical data were collected. A serum sample was collected for 25OHD and CRP analysis, and a stool sample was collected for fecal calprotectin (FC) measurement.
resultsThe mean serum 25OHD concentration of the group was 59.8 (24.9) nmol/L. After controlling for confounding variables, serum 25OHD inversely correlated with FC (r = -0.207, P = 0.030), particularly among those in clinical remission (r = -0.242, P = 0.022). The association between FC and 25OHD was further confirmed by linear regression (r = 31.3 %, P < 0.001). FC was lower in patients with 25OHD levels ≥75 nmol/L compared with levels <25 nmol/L [FC: 32.2 (16.3-98.2) vs 100.0 (34.4-213.5) μg/g, P = 0.004]. In the current study, however, 25OHD was not significantly associated with either CRP or CDAI.
conclusionCirculating 25OHD was significantly inversely associated with intestinal inflammation as determined by FC in CD. Subgroup analysis confirmed the association among those in clinical remission, but not in those with active disease. 25OHD was not associated with disease activity score (CDAI) or systemic inflammation (CRP). Vitamin D intervention studies are warranted to determine whether raising serum 25OHD levels in patients with CD may reduce intestinal inflammation as measured by FC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.