Evidence map›Paper›PMID 25756781›Full record

ArticleNano letters2015

Nanoscintillator-mediated X-ray inducible photodynamic therapy for in vivo cancer treatment.

Hongmin Chen, Geoffrey D Wang, Yen-Jun Chuang, Zipeng Zhen, Xiaoyuan Chen, Paul Biddinger, Zhonglin Hao, Feng Liu, Baozhong Shen, Zhengwei Pan and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nano letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 1 pooled it
22.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 1 synthesis or guideline pooled it, 378 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Self-illuminating liposome-derivedActa pharmaceutica Sinica. B · 2025
    Article
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  5. Review
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  8. Article
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  14. Single-Stage Microfluidic Synthesis Route for BaGdFInternational journal of molecular sciences · 2023
    Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review

45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Hongmin Chen†Department of Chemistry, University of Georgia, Athens, Georgia 30602, United States.
Geoffrey D Wang†Department of Chemistry, University of Georgia, Athens, Georgia 30602, United States.
Yen-Jun Chuang⊥College of Engineering, University of Georgia, Athens, Georgia 30602, United States.
Zipeng Zhen†Department of Chemistry, University of Georgia, Athens, Georgia 30602, United States.
Xiaoyuan Chen∇National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20852, United States.
Paul Biddinger¶Department of Pathology, Georgia Regents University, Augusta, Georgia 30912, United States.
Zhonglin Hao#Department of Internal Medicine, Medical College of Georgia, Georgia Regents University, Augusta, Georgia 30912, United States.
Feng Liu⊥College of Engineering, University of Georgia, Athens, Georgia 30602, United States.
Baozhong Shen§Department of Radiology, the Fourth Hospital of Harbin Medical University, Harbin 157, People's Republic of China.
Zhengwei Pan⊥College of Engineering, University of Georgia, Athens, Georgia 30602, United States.
Jin Xie†Department of Chemistry, University of Georgia, Athens, Georgia 30602, United States.
University of Georgia · USAugusta University · USGeorgia Regents Medical Center · USHarbin Medical University · CNNational Institutes of Health · US

Funding

Laboratory of Molecular Imaging and NanomedicineZIAEB000073 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI CHEN, XIAOYUAN · 2010 to 2020
$32.8M
Nanoplatform-based combinational therapy against breast cancer R00CA153772 · NCI · UNIVERSITY OF GEORGIA · PI XIE, JIN · 2011 to 2013
$710k
Intramural NIH HHS Z99 EB999999Intramural NIH HHS ZIA EB000073NCI NIH HHS 5R00CA153772NCI NIH HHS R00 CA153772
6 · The paper itself

Abstract

Photodynamic therapy is a promising treatment method, but its applications are limited by the shallow penetration of visible light. Here, we report a novel X-ray inducible photodynamic therapy (X-PDT) approach that allows PDT to be regulated by X-rays. Upon X-ray irradiation, the integrated nanosystem, comprised of a core of a nanoscintillator and a mesoporous silica coating loaded with photosensitizers, converts X-ray photons to visible photons to activate the photosensitizers and cause efficient tumor shrinkage.

Indexed as

Cell SurvivalDelayed-Action PreparationsLightNanocapsulesNeoplasms, ExperimentalPhotochemotherapyPhotosensitizing AgentsTreatment OutcomeX-RaysX-Ray TherapyDelayed-Action PreparationsNanocapsulesPhotosensitizing Agentscancer treatmentnanomedicinenanoscintillatorradioluminescence nanophosphorssinglet oxygenX-PDT

Identifiers

PMID25756781
PMCPMC5233724
OpenAlexW1971659905

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.