ArticleACS nano2015
Multivalent nanoparticle networks enable point-of-care detection of human phospholipase-A2 in serum.
Article in ACS nano, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 109 citations in OpenAlex.
- Lateral flow immunoassay using plasmonic scattering.Nature communications · 2025Article
- The protagonist of contemporary and emerging nanotechnology-based theranostics and therapeutic approaches in reshaping intensive care unit.Saudi medical journal · 2024Review
- Novel and portable test strip platform for rapid and sensitive on-site detection of procymidone pesticide.Mikrochimica acta · 2023Article
- Trends of respiratory virus detection in point-of-care testing: A review.Analytica chimica acta · 2023Review
- Recent Advances in Silica-Nanomaterial-Assisted Lateral Flow Assay.Bioengineering (Basel, Switzerland) · 2022Review
- Noble Metal Nanoparticle Biosensors: From Fundamental Studies toward Point-of-Care Diagnostics.Accounts of chemical research · 2022Review
- Supramolecular capture of highly polar amidosquaraine dye in water with nanomolar affinity and large turn-on fluorescence.Chemical communications (Cambridge, England) · 2021Article
- Improving the sensitivity of cellulose fiber-based lateral flow assay by incorporating a water-dissolvable polyvinyl alcohol dam.Cellulose (London, England) · 2021Article
- Phospholipase A2 (PLABiomedicines · 2020Article
- Lateral flow immunostrips for the sensitive and rapid determination of 8-hydroxy-2'-deoxyguanosine using upconversion nanoparticles.Mikrochimica acta · 2020Article
- Cationic liposomes for generic signal amplification strategies in bioassays.Analytical and bioanalytical chemistry · 2020Article
- Fluorescent Lipo-Beads for the Sensitive Detection of Phospholipase AACS biomaterials science & engineering · 2020Article
- Self-assembled colloidal gold superparticles to enhance the sensitivity of lateral flow immunoassays with sandwich format.Theranostics · 2020Article
- Nanoparticle-based assay for detection of S100P mRNA using surface-enhanced Raman spectroscopy.Journal of biomedical optics · 2019Article
- Recent advances in nanomedicine for sepsis treatment.Therapeutic delivery · 2018Review
- Diverse Applications of Nanomedicine.ACS nano · 2017Review
- A Review on Microfluidic Paper-Based Analytical Devices for Glucose Detection.Sensors (Basel, Switzerland) · 2016Review
- Gold Nanoparticles for Diagnostics: Advances towards Points of Care.Diagnostics (Basel, Switzerland) · 2016Review
- Dose-Dependent Response of Personal Glucose Meters to Nicotinamide Coenzymes: Applications to Point-of-Care Diagnostics of Many Non-Glucose Targets in a Single Step.Angewandte Chemie (International ed. in English) · 2016Article
- A Wash-Free Homogeneous Colorimetric Immunoassay Method.Theranostics · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
A rapid and highly sensitive point-of-care (PoC) lateral flow assay for phospholipase A2 (PLA2) is demonstrated in serum through the enzyme-triggered release of a new class of biotinylated multiarmed polymers from a liposome substrate. Signal from the enzyme activity is generated by the adhesion of polystreptavidin-coated gold nanoparticle networks to the lateral flow device, which leads to the appearance of a red test line due to the localized surface plasmon resonance effect of the gold. The use of a liposome as the enzyme substrate and multivalent linkers to link the nanoparticles leads to amplification of the signal, as the cleavage of a small amount of lipids is able to release a large amount of polymer linker and adhesion of an even larger amount of gold nanoparticles. By optimizing the molecular weight and multivalency of these biotinylated polymer linkers, the sensitivity of the device can be tuned to enable naked-eye detection of 1 nM human PLA2 in serum within 10 min. This high sensitivity enabled the correct diagnosis of pancreatitis in diseased clinical samples against a set of healthy controls using PLA2 activity in a point-of-care device for the first time.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.