Evidence map›Paper›PMID 25756285›Full record

ArticlePLoS medicine2015

HIV treatment-as-prevention research: taking the right road at the crossroads.

Richard Hayes, Sarah Fidler, Anne Cori, Christophe Fraser, Sian Floyd, Helen Ayles, Nulda Beyers, Wafaa El-Sadr, HPTN 071 (PopART) Study Team

Abstract read
In one paragraph

Article in PLoS medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Richard HayesLondon School of Hygiene & Tropical Medicine, Department of Infectious Disease Epidemiology, London, United Kingdom.
Sarah FidlerImperial College London, Department of Medicine, London, United Kingdom.
Anne CoriImperial College London, Department of Infectious Disease Epidemiology, London, United Kingdom.
Christophe FraserImperial College London, Department of Infectious Disease Epidemiology, London, United Kingdom.
Sian FloydLondon School of Hygiene & Tropical Medicine, Department of Infectious Disease Epidemiology, London, United Kingdom.
Helen AylesZAMBART, University of Zambia, School of Medicine, Lusaka, Zambia; London School of Hygiene & Tropical Medicine, Department of Clinical Research, London, United Kingdom.
Nulda BeyersDesmond Tutu TB Centre, University of Stellenbosch, Department of Paediatrics and Child Health, Stellenbosch, South Africa.
Wafaa El-SadrColumbia University, Mailman School of Public Health, New York, New York, United States of America.
HPTN 071 (PopART) Study Team

Funding

LOC: HIV Prevention Trials NetworkUM1AI068619 · NIAID · FAMILY HEALTH INTERNATIONAL · PI Sinead Delany-Moretlwe, RAPHAEL J LANDOVITZ · 2011 to 2026
$779.5M
SDMC: HPTN 084 Pregnancy SupplementUM1AI068617 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Elizabeth Renata Brown, Deborah J Donnell · 2011 to 2026
$204.9M
LC: HIV Prevention Trials Network - Laboratory Support for the SARS-CoV-2 Seroprevalence Study (CoVPN 5002)UM1AI068613 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SUSAN H ESHLEMAN, Mark A Marzinke · 2011 to 2026
$100.2M
Medical Research Council MR/K010174/1Medical Research Council MR/K012126/1NIAID NIH HHS UM1-AI06861NIAID NIH HHS UM1 AI068613NIAID NIH HHS UM1-AI068613NIAID NIH HHS UM1 AI068617NIAID NIH HHS UM1-AI068617NIAID NIH HHS UM1 AI068619PEPFAR
6 · The paper itself

Abstract

Reflecting on a Policy Forum article by Till Bärnighausen and colleagues, the HPTN 071 (PopART) Study Team consider ethical and study power concerns and the importance of the trial's future findings.

Indexed as

Health Services ResearchHIV InfectionsHumans

Identifiers

PMID25756285
PMCPMC4355412

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.