SynthesisThe American journal of gastroenterology2015
Serrated polyps and the risk of synchronous colorectal advanced neoplasia: a systematic review and meta-analysis.
Synthesis in The American journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03476434 (Panchromoendoscopy for the Surveillance of Serrated Polyposis Syndrome, a Multicenter, Prospective and Randomized Trial.), which is not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Panchromoendoscopy for the Surveillance of Serrated Polyposis Syndrome, a Multicenter, Prospective and Randomized Trial.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Association between dietary factors and colorectal serrated polyps: a systematic review and meta-analysis.Frontiers in nutrition · 2023Pooled it
- Impact of acetic acid chromoendoscopy on detection of serrated lesions in the proximal colon compared with white-light endoscopy.Endoscopy international open · 2026Article
- The CpG Island Methylator Phenotype Status in Synchronous and Solitary Primary Colorectal Cancers: Prognosis and Effective Therapeutic Drug Prediction.International journal of molecular sciences · 2024Review
- Clinicopathologic and endoscopic features of sessile serrated lesions and conventional adenomas: a large inpatient population-based study in China.Frontiers in oncology · 2024Article
- Current progress on the endoscopic features of colorectal sessile serrated lesions.World journal of clinical oncology · 2023Review
- Review
- Disparate age and sex distribution of sessile serrated lesions and conventional adenomas in an outpatient colonoscopy population-implications for colorectal cancer screening?International journal of colorectal disease · 2022Observational
- Plasma metabolomic profiles for colorectal cancer precursors in women.European journal of epidemiology · 2022Article
- Total polyp number may be more important than size and histology of polyps for prediction of metachronous high-risk colorectal neoplasms.BMC gastroenterology · 2022Article
- Detection and clinical characteristics of serrated polyps and conventional adenomas between patients in the outpatient and physical checkup unit receiving colonoscopy.International journal of colorectal disease · 2020Article
- Colorectal cancer susceptibility variants and risk of conventional adenomas and serrated polyps: results from three cohort studies.International journal of epidemiology · 2020Article
- Serrated lesions of the colon and rectum: Emergent epidemiological data and molecular pathways.Open medicine (Warsaw, Poland) · 2020Review
- Long Non-Coding RNA Cancer Susceptibility 9 (CASC9) Up-Regulates the Expression of ERBB2 by Inhibiting miR-193a-5p in Colorectal Cancer.Cancer management and research · 2020Article
- Hereditary or Not? Understanding Serrated Polyposis Syndrome.Current treatment options in gastroenterology · 2019Review
- An update on the morphology and molecular pathology of serrated colorectal polyps and associated carcinomas.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2019Review
- Cimp-Positive Status is More Representative in Multiple Colorectal Cancers than in Unique Primary Colorectal Cancers.Scientific reports · 2019Article
- Screening Relevance of Sessile Serrated Polyps.Clinical endoscopy · 2019Review
- Synchronous Neoplastic Lesions In Referred Patients With Colorectal Cancer: A Retrospective Cohort Study.Cancer management and research · 2019Article
- Simultaneous curative resection of double colorectal carcinoma with synchronous bilobar liver metastases.World journal of gastrointestinal oncology · 2018Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesSerrated polyps of the colon comprise a heterogeneous group of lesions with distinct histological and malignant features. The presence of serrated polyps has been associated with synchronous advanced neoplasia, although the magnitude of this relationship is unclear.
methodsUsing studies identified from systematic literature search up to February 2014, we performed a systematic review and meta-analysis to estimate the pooled prevalence of serrated polyps and their association with synchronous advanced neoplasia. Random-effects models were used to combine estimates from heterogeneous studies, and odds ratios (ORs) with 95% confidence intervals (CIs) were presented.
resultsNine studies with 34,084 participants were included. The mean age of subjects was 59.9±6.6 years and 52.5% of the subjects were male. Pooled prevalence of serrated polyps was 15.6% (95% CI, 10.3-22.9%). The pooled OR of advanced neoplasia in individuals with serrated polyps was 2.05 (95% CI, 1.38-3.04). Pooled analysis showed that the presence of proximal serrated polyps (OR=2.77, 95% CI, 1.71-4.46) and large serrated polyps (OR=4.10, 95% CI, 2.69-6.26) was associated with an increased risk of synchronous advanced neoplasia. The pooled OR for advanced neoplasia in individuals with proximal and large serrated polyps was 3.35 (95% CI, 2.51-4.46). Considerable heterogeneity was observed in most analyses.
conclusionsOur meta-analysis showed that serrated polyps are associated with a more than twofold increased risk of detection of synchronous advanced neoplasia. Individuals with proximal and large serrated polyps have the highest risk. These individuals deserve surveillance colonoscopy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.