Evidence map›Paper›PMID 25756220›Full record

ArticleEpidemiology (Cambridge, Mass.)2015

Drier air, lower temperatures, and triggering of paroxysmal atrial fibrillation.

Jennifer L Nguyen, Mark S Link, Heike Luttmann-Gibson, Francine Laden, Joel Schwartz, Benjamin S Wessler, Murray A Mittleman, Diane R Gold, Douglas W Dockery

Open access · greenAbstract read
In one paragraph

Article in Epidemiology (Cambridge, Mass.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Extreme Heat and Arrhythmia in Patients With Implanted Devices.Journal of the American Heart Association · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Observational
  13. Article
  14. Article
  15. Article
  16. Seasonal variations in cardiovascular disease.Nature reviews. Cardiology · 2017
    Review
  17. Article
  18. Article
  19. Winter Season Mortality: Will Climate Warming Bring Benefits?Environmental research letters : ERL [Web site] · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Jennifer L NguyenFrom the aDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY; bCardiac Arrhythmia Service, Division of Cardiology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA; cDepartment of Environmental Health, dDepartment of Epidemiology, Harvard School of Public Health, Boston, MA; eChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; and fCardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, MA.
Mark S Link
Heike Luttmann-Gibson
Francine Laden
Joel Schwartz
Benjamin S Wessler
Murray A Mittleman
Diane R Gold
Douglas W Dockery
Brigham and Women's Hospital · USEnvironmental Health · GBTufts Medical Center · USBeth Israel Deaconess Medical Center · USColumbia University · USHarvard University · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SUSAN A KORRICK · 1985 to 2026
$44.6M
Effect of Ambient Particles on Acute Stroke OnsetP01ES009825 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI DOCKERY, DOUGLAS W · 1999 to 2009
$17.4M
Training Program in Environmental EpidemiologyT32ES007069 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI LADEN, FRANCINE · 1985 to 2024
$13.9M
Interdisciplinary Training in Climate and HealthT32ES023770 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHAMAN, JEFFREY L · 2014 to 2019
$1.5M
Climate Change and Cardiac Vulnerability in HumansR21ES020194 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI GOLD, DIANE R, ZANOBETTI, ANTONELLA · 2011 to 2012
$463k
NIEHS NIH HHS P01 ES009825NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R21 ES020194NIEHS NIH HHS R21ES020194-01NIEHS NIH HHS T32 ES007069NIEHS NIH HHS T32ES007069NIEHS NIH HHS T32 ES023770NIEHS NIH HHS T32ES023770
6 · The paper itself

Abstract

backgroundThe few previous studies on the onset of paroxysmal atrial fibrillation and meteorologic conditions have focused on outdoor temperature and hospital admissions, but hospital admissions are a crude indicator of atrial fibrillation incidence, and studies have found other weather measures in addition to temperature to be associated with cardiovascular outcomes.

methodsTwo hundred patients with dual chamber implantable cardioverter-defibrillators were enrolled and followed prospectively from 2006 to 2010 for new onset episodes of atrial fibrillation. The date and time of arrhythmia episodes documented by the implanted cardioverter-defibrillators were linked to meteorologic data and examined using a case-crossover analysis. We evaluated associations with outdoor temperature, apparent temperature, air pressure, and three measures of humidity (relative humidity, dew point, and absolute humidity).

resultsOf the 200 enrolled patients, 49 patients experienced 328 atrial fibrillation episodes lasting ≥30 seconds. Lower temperatures in the prior 48 hours were positively associated with atrial fibrillation. Lower absolute humidity (ie, drier air) had the strongest and most consistent association: each 0.5 g/m decrease in the prior 24 hours increased the odds of atrial fibrillation by 4% (95% confidence interval [CI]: 0%, 7%) and by 5% (95% CI: 2%, 8%) for exposure in the prior 2 hours. Results were similar for dew point but slightly weaker.

conclusionsRecent exposure to drier air and lower temperatures were associated with the onset of atrial fibrillation among patients with known cardiac disease, supporting the hypothesis that meteorologic conditions trigger acute cardiovascular episodes.

Indexed as

AdultAgedAged, 80 and overAtrial FibrillationBostonCold TemperatureDefibrillators, ImplantableFemaleHumansHumidityMaleMiddle AgedWeather

Identifiers

PMID25756220
PMCPMC4502955
OpenAlexW2334688971

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.