ArticleRhinology2015
A computational study of functional endoscopic sinus surgery and maxillary sinus drug delivery.
Article in Rhinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Olfactory Dysfunction in Chronic Rhinosinusitis: Mechanisms, Diagnosis, and the Role of Endoscopic Sinus Surgery.Journal of clinical medicine · 2026Review
- Investigation of particle penetration in a nasal maxillary ostium with optimised T-junction geometry and pulsatile flow.Biomechanics and modeling in mechanobiology · 2025Article
- Comparison of Inhaled Drug Delivery in Patients With One- and Two-level Laryngotracheal Stenosis.The Laryngoscope · 2023Article
- Acoustic Aerosol Delivery: Assessing of Various Nasal Delivery Techniques and Medical Devices on Intrasinus Drug Deposition.Pharmaceuticals (Basel, Switzerland) · 2023Article
- A computational analysis on the impact of multilevel laryngotracheal stenosis on airflow and drug particle dynamics in the upper airway.Experimental and computational multiphase flow · 2023Article
- Lung inflammation and simulated airway resistance in infants with cystic fibrosis.Respiratory physiology & neurobiology · 2021Article
- Comparative study of simulated nebulized and spray particle deposition in chronic rhinosinusitis patients.International forum of allergy & rhinology · 2019Article
- Computational Analysis of the Mature Unilateral Cleft Lip Nasal Deformity on Nasal Patency.Plastic and reconstructive surgery. Global open · 2019Article
- Diseases of the nasal cavity.Handbook of clinical neurology · 2019Review
- Investigating the effects of laryngotracheal stenosis on upper airway aerodynamics.The Laryngoscope · 2018Article
- Ethmoidectomy combined with superior meatus enlargement increases olfactory airflow.Laryngoscope investigative otolaryngology · 2017Article
- Finite Element Model and Validation of Nasal Tip Deformation.Annals of biomedical engineering · 2017Article
- Article
Corrections and comments
- Erratum issued
- Erratum issued
Authors and funding
9 authors.
Funding
Abstract
backgroundTopical medication is increasingly used following functional endoscopic sinus surgery (FESS). Information on particle sizes that maximise maxillary sinus (MS) delivery is conflicting, and the effect of antrostomy size on delivery is unclear. The purpose of this study was to estimate antrostomy and particle size effects on topical MS drug delivery. METHODOLOGY: Sinonasal reconstructions were created from a pre- and a post-FESS CT scan in each of four chronic rhinosinusitis patients. Additional models were created from each post-FESS reconstruction representing four alternative antrostomy sizes. Airflow and particle deposition were simulated in each reconstruction using computational fluid dynamics for nebulised and sprayed delivery.
resultsMS ventilation and drug delivery increased following FESS, the largest virtual antrostomy led to greatest delivery, and MS delivery was sensitive to particle size. Particles within a 5-18 μm and 5-20 μm size range led to peak MS deposition for nebulised and sprayed particles, respectively. Post-FESS increases in drug delivery varied across individuals and within individuals by the type of antrostomy created.
conclusionOur findings suggest that FESS, particularly with larger antrostomies, improves topical drug delivery, and that certain particle sizes improve this delivery. Further research is needed to contextualise these findings with other post-surgical effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.