Evidence map›Paper›PMID 25756045›Full record

SynthesisBioMed research international2015

Impact of ischemic preconditioning on outcome in clinical liver surgery: a systematic review.

Michael J J Chu, Ryash Vather, Anthony J R Hickey, Anthony R J Phillips, Adam S J R Bartlett

Open access · hybridAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Current Antioxidant Treatments in Organ Transplantation.Oxidative medicine and cellular longevity · 2016
    Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Michael J J ChuDepartment of Surgery, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Ryash VatherDepartment of Surgery, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Anthony J R HickeyMaurice Wilkins Centre for Biodiscovery, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand ; School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Anthony R J PhillipsDepartment of Surgery, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand ; New Zealand Liver Transplant Unit, Auckland City Hospital, Private Bag 92024, Auckland 1023, New Zealand.
Adam S J R BartlettDepartment of Surgery, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand ; School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand ; New Zealand Liver Transplant Unit, Auckland City Hospital, Private Bag 92024, Auckland 1023, New Zealand.
University of Auckland · NZAuckland City Hospital · NZMaurice Wilkins Centre · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIschemia-reperfusion injury is a major cause of post-liver-surgery complications. Ischemic preconditioning (IPC) has been demonstrated to protect against ischemia-reperfusion injury. Clinical studies have examined IPC in liver surgery but with conflicting results. This systematic review aimed to evaluate the effects of IPC on outcome in clinical liver surgery.

methodsAn electronic search of OVID Medline and Embase databases was performed to identify studies that reported outcomes in patients undergoing liver surgery subjected to IPC. Basic descriptive statistics were used to summarise data from individual clinical studies.

results1093 articles were identified, of which 24 met the inclusion criteria. Seven topics were selected and analysed by subgroup. There were 10 studies in cadaveric liver transplantation, 2 in living-related liver transplantation, and 12 in liver resection. IPC decreases hepatocellular damage in liver surgery as determined by transaminases but does not translate to any significant clinical benefit in orthotopic liver transplant or liver resection.

conclusionsAvailable clinical evidence does not support routine use of IPC in liver surgery as it does not offer any apparent benefit in perioperative outcome. Further clinical studies will need to be carried out to determine the subset of patients that will benefit from IPC.

Indexed as

Ischemic PreconditioningCadaverHepatectomyHumansLiverLiver TransplantationPerioperative PeriodReperfusion InjuryTreatment Outcome

Identifiers

PMID25756045
PMCPMC4338382
OpenAlexW2136906184

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.