ArticleHawai'i journal of medicine & public health : a journal of Asia Pacific Medicine & Public Health2015
Recurrent papillary thyroid carcinoma with pleural metastasis diagnosed by effusion cytology: a report of cases with clinicopathologic correlation.
Article in Hawai'i journal of medicine & public health : a journal of Asia Pacific Medicine & Public Health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Pleural metastases from differentiated thyroid cancer: clinical features and long-term outcomes.European thyroid journal · 2025Article
- Pleural effusion metastatic papillary thyroid carcinoma with dedifferentiation: a case report and review of the literature.Frontiers in oncology · 2025Article
- Lenvatinib treatment strategy for thyroid carcinoma with malignant pleurisy: a case report.Gland surgery · 2024Article
- Metastatic papillary thyroid carcinoma in pleural effusion: a case report and review of the literature.Journal of medical case reports · 2023Review
- Pleural effusion as a novel prognostic factor in metastatic thyroid carcinoma.Endocrine connections · 2020Article
- Pleural fluid due to papillary thyroid cancer.Oncology letters · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Papillary thyroid carcinoma (PTC) is typically an indolent disease characterized by slow growth and a favorable prognosis. In rare instances, this disease may metastasize to the pleura and manifest as a malignant pleural effusion. We report 3 female patients of Japanese/Okinawan ancestry with a history of PTC who presented with hydrothorax. Cytologic examination in conjunction with immunohistochemical staining enabled a definitive diagnosis of metastatic PTC. Molecular analysis of the mitogen activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K) pathways demonstrated the presence of the v-raf murine sarcoma viral oncogene homolog B (BRAF)(V600E) mutation in 2 of our 3 patients, with the absence of any other clinically significant mutations in all cases. Further investigation is necessary to elucidate the molecular and environmental mechanisms involved in this aggressive manifestation of PTC.
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Identifiers
25755913PMC4338567W2318898387What OpenQuestion holds
Registered trials
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