ArticleIranian journal of pediatrics2014
Scrub typhus in children at a tertiary hospital in north India: clinical profile and complications.
Article in Iranian journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 67 citations in OpenAlex.
- Review
- Article
- Frequency and distribution of eschar in patients with scrub typhus in India: systematic review of literature and meta-analysis.Le infezioni in medicina · 2024Review
- Once Forgotten Now Re-emerging: Scrub Typhus Infection in Pediatric Patients From North West India.Cureus · 2023Article
- Predictors of Severity of Scrub Typhus in Children Requiring Pediatric Intensive Care Admission.Journal of pediatric intensive care · 2022Article
- Scrub Typhus in Paediatric Age Group at a Tertiary Care Centre of Eastern India: Clinical, Biochemical Profile and Complications.Journal of family medicine and primary care · 2022Article
- Seroprevalence trends of Scrub typhus among the febrile patients of Northern India: A prospective cross-sectional study.Journal of family medicine and primary care · 2021Article
- Scrub Typhus among Febrile Children in a Tertiary Care Center of Central Nepal: A Descriptive Cross-sectional Study.JNMA; journal of the Nepal Medical Association · 2021Article
- Clinical Profile and Predictors of Intensive Care Unit Admission in Pediatric Scrub Typhus: A Retrospective Observational Study from North India.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2020Article
- Scrub Typhus in Children at Tribhuvan University Teaching Hospital in Nepal.Pediatric health, medicine and therapeutics · 2020Article
- Clinical profile, complications and outcome of scrub typhus in children: A hospital based observational study in central Nepal.PloS one · 2019Observational
- Predictors of Severity in Pediatric Scrub Typhus.Indian journal of pediatrics · 2018Observational
- Comparison of Scrub Typhus With and Without Meningitis.Indian journal of pediatrics · 2017Article
- Acute Encephalitis Syndrome and Scrub Typhus in India.Emerging infectious diseases · 2017Article
- Scrub Typhus in a Tertiary Care Hospital in North India.The American journal of tropical medicine and hygiene · 2016Article
- Risk Factors Associated with Adult Scrub Typhus Cases in a Tertiary Care Hospital - A Case Control Study.Indian journal of community medicine : official publication of Indian Association of Preventive & Social MedicineArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo study the clinical profile and complications of childhood scrub typhus.
methodsProspective observational study of 66 children with scrub typhus, admitted to a tertiary hospital in north India, during the period between January 2011 and December 2012. The diagnosis was confirmed by serology. Findings : All children presented with fever. Other common symptoms were vomiting (56%), facial swelling (52%), cough (35%), abdominal pain (33%), breathlessness (29%) and decreased urine output (29%). High grade fever (>101 (o)F) was recorded in 91% of children. Other common signs were hepatomegaly, splenomegaly, edema, tender lymphadenopathy and hypotension, observed in 82%, 59%, 39%, 38% and 36% of cases, respectively. An eschar and a maculopapular rash each were observed in 20% of patients. Meningoencephalitis (30.3%), severe thrombocytopenia (27.2%), shock (25.8%), acute kidney injury (16.7%) and hepatitis (13.6%) were the most common complications observed in these children. Other common complications were acute respiratory distress syndrome, respiratory failure requiring ventilation, bronchopneumonia and myocarditis. Ninety percent of children became afebrile within 48 hours of initiating an appropriate antibiotic. Median time to defervescence was 22 hours. The overall mortality rate was 7.5%. Causes of death were refractory shock, meningoencephalitis, acute respiratory distress syndrome, bronchopneumonia, acute kidney injury and myocarditis.
conclusionPediatricians should keep a high index of suspicion for scrub typhus in any febrile child having a maculopapular rash, hepatosplenomegaly, tender lymphadenopathy, thrombocytopenia and features suggestive of capillary leak. Pending serological confirmation, empirical therapy with doxycycline or azithromycin should be started, as delay in treatment would result in life threatening complications.
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25755859PMC4339561W1759107217What OpenQuestion holds
Registered trials
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