ArticleInternational journal of clinical and experimental pathology2015
The distribution of Mn2+ in rabbit eyes after topical administration for manganese-enhanced MRI.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- Longitudinal manganese-enhanced magnetic resonance imaging of neural projections and activity.NMR in biomedicine · 2022Review
- Manganese-Enhanced Magnetic Resonance Imaging: Application in Central Nervous System Diseases.Frontiers in neurology · 2020Review
- Applications of Manganese-Enhanced Magnetic Resonance Imaging in Ophthalmology and Visual Neuroscience.Frontiers in neural circuits · 2019Review
- Manganese-Enhanced Magnetic Resonance Imaging: Overview and Central Nervous System Applications With a Focus on Neurodegeneration.Frontiers in aging neuroscience · 2018Review
- Ability of Mn(2+) to Permeate the Eye and Availability of Manganese-enhanced Magnetic Resonance Imaging for Visual Pathway Imaging via Topical Administration.Chinese medical journal · 2016Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo analyze the distribution of Mn(2+) in rabbit eyes after topical administration of Mncl2 for manganese-enhanced MRI.
methodsForty-eight Chinese white rabbits were divided into three groups. In group 1 (n = 4), the baseline concentration of Mn(2+) in aqueous, vitreous and serum samples were analyzed. In group 2 and 3, the rabbits received one topical instillation (20 μL) of Mncl2 (1 mol • L(-1)). In group 2 (n = 40), aqueous, vitreous and serum samples were collected and analyzed at predetermined time points (0.5, 1, 2, 4, 6, 12, 24, 48, 72 and 168 hours postdose). Assays were performed using inductively coupled plasma-mass spectrometer (ICP-MS). In group 3 (n = 4), after topical administration of Mncl2, dynamic manganese-enhanced MRI (MEMRI) was performed at predetermined time points. The signal-to-noise ratio (SNR) was calculated to evaluate the enhancements of eyes.
resultsAfter topical administration, the maximum concentrations of Mn(2+) in the aqueous and vitreous samples were 11.1641 ± 0.7202 (2 hours) and 1.5622 ± 0.1567 (12 hours). In group 3, the maximum enhancement of aqueous humor (SNR = 108.81 ± 10.65) appeared at 2 hours postdose, whereas, no significant changes were detected in vitreous.
conclusionMn(2+) could distribute into aqueous humor rapidly after topical administration of Mncl2, whereas, the concentration of Mn(2+) in vitreous body fluctuated in a narrow range over the course. The uptake of Mn(2+) in retina may involve several different pathways.
Indexed as
Identifiers
25755783PMC4348895W2406628970What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.