ArticleInternational journal of clinical and experimental pathology2015
Downregulation of ring-finger protein 43 in glioma associates with poor prognosis.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Bioinformatic Analysis of RNF43 and Its Co-expressors As Prognostic Biomarkers for Gastric Cancer.Cureus · 2025Article
- RNF115 promotes lung adenocarcinoma through Wnt/β-catenin pathway activation by mediating APC ubiquitination.Cancer & metabolism · 2021Article
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Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ring-finger protein 43 (RNF43) has been identified as a RING-type E3 ubiquitin ligase. The overexpression of RNF43 results in a significant enhancement of cell growth, and knockdown of the expression of RNF43 by siRNAs exerts a growth-suppressing effect. RNF43 has been proposed as a tumor suppressor in colorectal cancers. However, its expression significance in glioma has not been well studied. In the present study, we found that the decreased expression of RNF43 was associated with poor prognosis by the Kaplan-Meier survival analysis (P < 0.001). Importantly, multivariate analysis suggested RN43 as an independent predictor of overall survival ([hazard ratio (HR) 0.547, 95% confidence interval (95% CI) 0.382-0.784, P = 0.001]). Collectively, our study demonstrated that RNF43 could be served as a potential prognostic marker for patients with this deadly disease.
Indexed as
Identifiers
25755738PMC4348829W68477858What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.