ArticleInternational journal of clinical and experimental pathology2015
Primary intracranial Ewing's sarcoma with unusual features.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Diagnosis, treatment, and postoperative follow-up of intracranial Ewing sarcoma (EWS): a case report.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Recurrent Primary Intracranial Ewing Sarcoma With Parietal Bone Involvement: A Case Report.Clinical medicine insights. Case reports · 2026Article
- Article
- Primary Ewing's Sarcoma affecting the Central Nervous System: A single-center experience and Narrative review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Review
- Primary intracranial peripheral primitive neuroectodermal tumor: lessons from an exceptionally rare neoplasm. Illustrative case.Journal of neurosurgery. Case lessons · 2024Article
- Primary Intracranial Ewing Sarcoma With an Unusual Presentation: A Case Report.Brain tumor research and treatment · 2024Article
- Primary and metastatic cerebral Ewing's sarcoma: A case report about a rare entity and literature review.Surgical neurology international · 2024Article
- Primary Intracranial Ewing Sarcoma WithBrain tumor research and treatment · 2023Article
- Primary intracranial extraosseous Ewing's sarcoma of the skull base in an elderly adult: illustrative case.Journal of neurosurgery. Case lessons · 2022Article
- Primary intracranial peripheral primitive neuroectodermal tumor in an adult patient with aphasia: A rare case report.Clinical case reports · 2022Article
- Case report: Primary intracranial EWs/PNET in adults: Clinical experience and literature review.Frontiers in oncology · 2022Article
- Multifocal primary central nervous system Ewing sarcoma presenting with intracranial hemorrhage and leptomeningeal dissemination: illustrative case.Journal of neurosurgery. Case lessons · 2021Article
- Primary intracranial Ewing sarcoma/ peripheral primitive neuroectodermal tumor, an entity of unacquaintance: a series of 8 cases.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- The spectrum of rare central nervous system (CNS) tumors with EWSR1-non-ETS fusions: experience from three pediatric institutions with review of the literature.Brain pathology (Zurich, Switzerland) · 2021Review
- Primary and Metastatic Intracranial Ewing Sarcoma at Diagnosis: Retrospective International Study and Systematic Review.Cancers · 2020Review
- Primary Intracranial Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor Mimicking Meningioma: A Case Report and Literature Review.Frontiers in oncology · 2020Article
- Intracranial Ewing sarcoma: four pediatric examples.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018Article
- Synthetic treatment of intracranial peripheral primitive neuroectodermal tumor with multiple metastasis: a case report.OncoTargets and therapy · 2016Article
- Extraosseous Primary Intracranial Ewing Sarcoma/peripheral Primitive Neuroectodermal Tumor: Series of Seven Cases and Review of Literature.Asian journal of neurosurgeryArticle
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pediatric primary "small round blue cell" tumors in the CNS represent several entities, some more common than others. Ewing sarcoma/peripheral primitive neuroectodermal tumor (ES/pPNET) is rare and must be distinguished from other tumors such as medulloblastoma [1, 2], atypical rhabdoid/teratoid tumor, ependymomal tumors, metastatic sarcomas, hematologic malignancies, and other mimics. Although therapy for ES/pPNET is effective, it brings severe side effects, including cardiac toxicity, making correct recognition important [3]. As small blue cell tumors look similar, diagnosis often depends on special stains, immunohistochemistry, and molecular techniques. While the combination of membranous immunohistochemical reactivity for CD99 with cytoplasmic glycogen provides effective screening, demonstration of characteristic translocations of EWSR1 (chromosome 22) or FUS (chromosome 16) by fluorescent in situ hybridization (FISH) can confirm the diagnosis. We are reporting three primary ES/pPNET of the CNS, two of which occurred in children. While the adult case demonstrates the classic histopathology, the two pediatric cases have histopathology that significantly deviates from the usual. One is suggestive of a primary sarcoma, and the other mimics an ependymoma, but all three cases are confirmed with FISH. These observations suggest that primary ES in the CNS may have histology different from the classic morphology and a high index of suspicion should be maintained in order to make the correct diagnosis. A search of the literature suggests that these tumors are most frequently seen in children and young adults. Imaging often shows a supratentorial enhancing mass that touches the leptomeninges. Survival over three years is good but long term prognosis is unknown [3, 4].
Indexed as
Identifiers
25755713PMC4348914W89732738What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.