Evidence map›Paper›PMID 25755549›Full record

ReviewJournal of clinical and experimental hepatology2014

Consensus Statement of HCV Task Force of the Indian National Association for Study of the Liver (INASL). Part II: INASL Recommendations for Management of HCV in India.

Pankaj Puri, Anil C Anand, Vivek A Saraswat, Subrat K Acharya, Shiv K Sarin, Radha K Dhiman, Rakesh Aggarwal, Shivaram P Singh, Deepak Amarapurkar, Anil Arora and 22 more

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of clinical and experimental hepatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. A systematic review of standard treatment guidelines in India.The Indian journal of medical research · 2019
    Pooled it
  2. Trial
  3. Efficacy and safety of sofosbuvir-based therapy for chronic hepatitis C infection in "real-life" cohort.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2016
    Trial
  4. Article
  5. Article
  6. Article
  7. Review
  8. Treatment of chronic genotype-3 hepatitis C virus infection using direct-acting antiviral agents: An Indian experience.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2017
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Hepatobiliary quiz 11 (2014).Journal of clinical and experimental hepatology · 2014
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 20 institutions in 1 country.

Pankaj PuriDepartment of Gastroenterology, Army Hospital (R & R), New Delhi 110010, India.
Anil C AnandDepartment of Gastroenterology and Hepatology, Indraprastha Apollo Hospital, New Delhi 110076, India.
Vivek A SaraswatDepartment of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical, Sciences, Lucknow, Uttar Pradesh 221016, India.
Subrat K AcharyaDepartment of Gastroenterology, All India Institute of Medical Sciences, New Delhi 110029, India.
Shiv K SarinInstitute of Liver and Biliary Sciences, Vasant Kunj, New Delhi 110070, India.
Radha K DhimanDepartment of Hepatology, Postgraduate Institute of Medical Education and, Research, Chandigarh 160012, India.
Rakesh AggarwalDepartment of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical, Sciences, Lucknow, Uttar Pradesh 221016, India.
Shivaram P SinghDepartment of Gastroenterology, SCB Medical College, Cuttack, Odisha 753007, India.
Deepak AmarapurkarDepartment of Gastroenterology, Bombay Hospital, Mumbai, Maharashtra 400020, India.
Anil AroraDepartment of Gastroenterology and Hepatology, Sir Ganga Ram Hospital, New Delhi 110060, India.
Mohinish ChhabraDepartment of Gastroenterology, Fortis Hospital, Mohali, Punjab 160047, India.
Kamal ChetriDepartment of Gastroenterology, International Hospital, Guwahati, Assam 781005, India.
Gourdas ChoudhuriDepartment of Gastroenterology, Fortis Hospital, Gurgaon, Haryana 122002, India.
Vinod K DixitDepartment of Gastroenterology, Banaras Hindu University, Varanasi, Uttar Pradesh 221005, India.
Ajay DusejaDepartment of Hepatology, Postgraduate Institute of Medical Education and, Research, Chandigarh 160012, India.
Ajay K JainDepartment of Gastroenterology, Choithram Hospital & Research Centre, Indore, Madhya Pradesh 452014, India.
Dharmesh KapoorDepartment of Gastroenterology, Global Hospital, Hyderabad, Andhra Pradesh 500004, India.
Premashis KarDepartment of Gastroenterology, LNJP Hospital, and Maulana Azad Medical College, New Delhi 110002, India.
Abraham KoshyDepartment of Hepatology, Lakeshore Hospital, Cochin, Kerala 682304, India.
Ashish KumarDepartment of Gastroenterology and Hepatology, Sir Ganga Ram Hospital, New Delhi 110060, India.
Kaushal MadanDepartment of Gastroenterology, Medanta Medicity, Gurgaon, Haryana 122001, India.
Sri P MisraDepartment of Gastroenterology, Moti Lal Nehru Medical College, Allahabad, Uttar Pradesh 211001 India.
Mohan V G PrasadDepartment of Gastroenterology, VGM Hospital, Coimbatore, Tamil Nadu 641005, India.
Aabha NagralDepartment of Gastroenterology, Jaslok Hospital, Mumbai, Maharashtra 400026, India.
Amarendra S PuriDepartment of Gastroenterology, GB Pant Hospital, New Delhi 110002, India.
R JeyamaniDepartment of Gastroenterology, Christian Medical College, Vellore, Tamil Nadu 632004, India.
Sanjiv SaigalDepartment of Gastroenterology, Medanta Medicity, Gurgaon, Haryana 122001, India.
Samir ShahDepartment of Gastroenterology, Global Hospital, Mumbai, Maharashtra 400078, India.
Praveen K SharmaDepartment of Medicine, Armed Forces Medical College, Pune, Maharashtra 411040, India.
Ajit SoodDepartment of Gastroenterology, Dayanand Medical College, Ludhiana, Punjab 141001, India.
Sandeep TharejaDepartment of Gastroenterology, Army Hospital (R & R), New Delhi 110010, India.
Manav WadhawanDepartment of Gastroenterology and Hepatology, Indraprastha Apollo Hospital, New Delhi 110076, India.
Army Hospital Research and Referral · INGlobal Hospitals · INIndraprastha Apollo Hospitals · INMedanta The Medicity · INPost Graduate Institute of Medical Education and Research · INSanjay Gandhi Post Graduate Institute of Medical Sciences · INSir Ganga Ram Hospital · INAll India Institute of Medical Sciences · INArmed Forces Medical College · INBanaras Hindu University · INBombay Hospital · INChoithram Hospital and Research Centre · INChristian Medical College & Hospital · INDayanand Medical College & Hospital · INFortis Hospital · INFortis Hospital · INGovind Ballabh Pant Hospital · INInstitute of Liver and Biliary Sciences · INJaslok Hospital · INKG Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The estimated prevalence of hepatitis C virus (HCV) infection in India is between 0.5 and 1.5% with hotspots showing much higher prevalence in some areas of northeast India, in some tribal populations and in certain parts of Punjab. Genotype 3 is the most prevalent type of infection. Recent years have seen development of a large number of new molecules that are revolutionizing the treatment of hepatitis C. Some of the new directly acting agents (DAAs) like sofosbuvir have been called game-changers because they offer the prospect of interferon-free regimens for the treatment of HCV infection. These new drugs have not yet been approved in India and their cost and availability is uncertain at present. Till these drugs become available at an affordable cost, the treatment that was standard of care for the whole world before these newer drugs were approved should continue to be recommended. For India, cheaper options, which are as effective as the standard-of-care (SOC) in carefully selected patients, are also explored to bring treatment within reach of poorer patients. It may be prudent to withhold treatment at present for selected patients with genotype 1 or 4 infection and low levels of fibrosis (F1 or F2), and for patients who are non-responders to initial therapy, interferon intolerant, those with decompensated liver disease, and patients in special populations such as stable patients after liver and kidney transplantation, HIV co-infected patients and those with cirrhosis of liver.

Indexed as

ALT, alanine amintraonsferaseANC, absolute neutrophil countanti-HCV, antibody to HCVantiviral therapyAST, aspartate aminotransferaseCH–C, Chronic Hepatitis Cchronic hepatitisCKD, chronic kidney diseaseCTP, Child-Turcotte-PughEIA, enzyme immunoassayETR, end-of-treatment responseEVR, early virological responseGRADE, Grading of Recommendations Assessment, Development and EvaluationHCV, hepatitis C virushepatitis C virusHIV, Human immunodeficiency virusIFNa, interferon alfaINASL, Indian National Association for Study of the LiverPCR, polymerase chain reactionPeg-IFNa, pegylated interferon alfaRBV, RibavirinRVR, rapid virological responseSOC, standard of careSVR, sustained virological responseULN, upper limit of normal

Identifiers

PMID25755549
PMCPMC4116713
OpenAlexW2062307261

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.