Evidence map›Paper›PMID 25755530›Full record

ArticleJournal of clinical and experimental hepatology2014

HLA DRB1 Alleles Discriminate the Manifestation of Autoimmune Hepatitis as Type 1 or Type 2 in North Indian Population.

Navchetan Kaur, Ranjana W Minz, Shashi Anand, Biman Saikia, Ritu Aggarwal, Ashim Das, Babu R Thapa, Yogesh K Chawla

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and experimental hepatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Guideline
  2. Review
  3. Article
  4. HLA, gut microbiome and hepatic autoimmunity.Frontiers in immunology · 2022
    Review
  5. Review
  6. Article
  7. Review
  8. Frequency of OBI among Patients with Autoimmune Hepatitis.Asian Pacific journal of cancer prevention : APJCP · 2020
    Article
  9. Autoimmune Hepatitis in the Asia-Pacific Area.Journal of clinical and translational hepatology · 2018
    Review
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Navchetan KaurDepartment of Immunopathology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
Ranjana W MinzDepartment of Immunopathology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
Shashi AnandDepartment of Immunopathology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
Biman SaikiaDepartment of Immunopathology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
Ritu AggarwalDepartment of Immunopathology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
Ashim DasDepartment of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
Babu R ThapaDepartment of Paediatric Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
Yogesh K ChawlaDepartment of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
Post Graduate Institute of Medical Education and Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAutoimmune hepatitis is a polygenic disorder of unknown etiology, where genetic factors affect the occurrence and clinical phenotype of the disease. It has been reported as a rare disease entity in the Indian subcontinent. This study was undertaken to investigate the association of HLA alleles with autoimmune hepatitis type 1 and type 2 in north Indian population and to analyze if distinct human leukocyte antigen (HLA) alleles help in characterization of the subtypes of autoimmune hepatitis.

methodsSixty-eight patients with autoimmune hepatitis and 128 healthy controls were recruited in the study. Out of 68 patients, 55 were diagnosed with autoimmune hepatitis type 1 and 13 with autoimmune hepatitis type 2. The patients and the controls were typed for HLA class II alleles by PCR-SSP method.

resultsHLA DRB1*04 and DRB1*08 were found to be significantly associated with autoimmune hepatitis type 1 in north Indian population. It was also observed that DRB1*04, DRB1*13 were significantly associated with pediatric autoimmune hepatitis type 1 and DRB1*08 was significantly associated with adult autoimmune hepatitis type 1. DRB1*14 was significantly associated with autoimmune hepatitis type 2.

conclusionThe study indicates that autoimmune hepatitis in north Indian population is associated with HLA alleles that may help to discriminate the subtypes as autoimmune hepatitis type 1 and type 2. The study also highlights the ethnic variations in the Indian subcontinent in context to the genetic association of HLA with autoimmune diseases.

Indexed as

AASLD, American Association for the Study of the LiverAIH, autoimmune hepatitisANA, antinuclear antibodyASMA, anti smooth muscle antibodyautoimmune hepatitisCI, confidence intervalethnic variationsHLA, human leukocyte antigenhuman leukocyte antigenIAHG, International Autoimmune Hepatitis GroupIIF, indirect immuno florescenceLKM, liver kidney microsomalMb, megabaseMHC, major histocompatibility complexnorth IndiaOR, odds ratioPCR-SSP, polymerase chain reaction-sequence specific primersRR, relative risk

Identifiers

PMID25755530
PMCPMC4017209
OpenAlexW1965399301

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.