Evidence map›Paper›PMID 25755505›Full record

ArticleJournal of clinical and experimental hepatology2013

MicroRNAs in Liver Disease: Bench to Bedside.

Nihar Shah, James E Nelson, Kris V Kowdley

Open access · bronzeAbstract read
In one paragraph

Article in Journal of clinical and experimental hepatology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 29 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. miR-200a controls hepatic stellate cell activation and fibrosis via SIRT1/Notch1 signal pathway.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2017
    Article
  12. Review
  13. Review
  14. Hepatobiliary quiz-8 (2013).Journal of clinical and experimental hepatology · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Nihar ShahLiver Center of Excellence, Digestive Disease Institute, Virginia Mason Medical Center, Seattle, WA, United States.
James E NelsonBenaroya Research Institute, Virginia Mason Medical Center, Seattle, WA, United States.
Kris V KowdleyLiver Center of Excellence, Digestive Disease Institute, Virginia Mason Medical Center, Seattle, WA, United States ; Benaroya Research Institute, Virginia Mason Medical Center, Seattle, WA, United States.
Virginia Mason Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRs) are small non-coding RNAs that negatively regulate gene expression by pairing with partially complementary target sequences in the 3'UTRs of mRNAs to promote degradation and/or block translation. Aberrant miR expression is associated with development of multiple diseases including hepatic diseases. The role of miRs in the regulation of gene expression and rapid progress in the field of microRNA research are resulting in momentum toward development of diagnostic markers and novel therapeutic strategies for human liver diseases. Recent studies provide clear evidence that miRs are abundant in the liver and modulate a diverse spectrum of biological functions, thereby supporting an association between alterations of miR homeostasis and pathological liver diseases. Here we review the role of miRs in liver as their physiological and pathological importance has been demonstrated in metabolism, immunity, viral hepatitis, oncogenesis, fatty liver diseases (alcoholic and non-alcoholic), drug-induced liver injury, fibrosis as well as acute liver failure.

Indexed as

ALD, alcoholic liver diseaseALF, acute liver failureDILI, drug-induced liver injurydown-regulationHBV, hepatitis B virusHCC, hepatocellular carcinomaHCV, hepatitis C virusHSC, hepatic stellate cellIFN, interferonlivermicroRNAmiR-122miRs/miRNA, microRNANAFLD, non-alcoholic fatty liver diseaseNASH, non-alcoholic steatohepatitisPPAR γ, peroxisome proliferator-activated receptor γTGF, transforming growth factorTNF, tumor necrosis factorup-regulationUTR, untranslated region

Identifiers

PMID25755505
PMCPMC3940370
OpenAlexW2007131306

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.