Evidence map›Paper›PMID 25755502›Full record

ReviewJournal of clinical and experimental hepatology2013

Hepatotropic viral infection associated systemic vasculitides-hepatitis B virus associated polyarteritis nodosa and hepatitis C virus associated cryoglobulinemic vasculitis.

Aman Sharma, Kusum Sharma

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of clinical and experimental hepatology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 35 citations in OpenAlex.

  1. Frequency of dermatological manifestations in patients with chronic hepatitis C infections.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. On hepatitis B virus and vasculitis.Rheumatology international · 2018
    Article
  14. Article
  15. Viral-Associated GN: Hepatitis B and Other Viral Infections.Clinical journal of the American Society of Nephrology : CJASN · 2017
    Review
  16. Hepatobiliary quiz-8 (2013).Journal of clinical and experimental hepatology · 2013
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Aman SharmaDepartment of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
Kusum SharmaDepartment of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
Post Graduate Institute of Medical Education and Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Two hepatotropic viruses have been shown to have causal relationship with systemic vasculitis-hepatitis B with classical polyarteritis nodosa and hepatitis C with cryoglobulinemic vasculitis. The present paper provides an updated overview on the clinical presentations and management of these vasculitides. HBV associated PAN patients have higher weight loss, peripheral neuropathy, mononeuritis multiplex, abdominal pain, gastrointestinal manifestations requiring surgery, cardiomyopathy, orchitis, hypertension, and/or elevated transaminase levels. Microaneurysms are also more common in mesenteric artery. Skin manifestations, however are less common. These patients also have a severe disease as suggested by higher five factor score and higher BVAS. Though relapses are less common, mortality is higher in patients with HBV PAN as compared to non HBV PAN. Plasmapheresis has a role in treatment in clearing off immune complexes. The common clinical manifestations of HCV associated cryoglobulinemic vasculitis are skin lesions, peripheral neuropathy, glomerulonephritis, arthritis, and sicca symptoms. Though combination therapy comprising of pegylated interferon α and ribavirin is the first line of management, immunotherapy is needed for severe or life threatening manifestations. Recent randomized trials have shown the efficacy of rituximab in such situations.

Indexed as

ANCA, anti neutrophilic cytoplasmic antibodiesBVAS, Birmingham vasculitis activity scoreCHCC, Chapel Hill Consensus classification criteriacryoglobulinemic vasculitisFFS, five factor scoreFVG, French vasculitis groupHBVHBV, hepatitis b virusHBV, hepatitis c virusHCVMPA, microscopic polyangiitisMPO, myeloperoxidasePAN, polyarteritis nodosaPE, plasma exchangepolyarteritis nodosa

Identifiers

PMID25755502
PMCPMC4216827
OpenAlexW2008089400

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.