Evidence map›Paper›PMID 25755489›Full record

ReviewJournal of clinical and experimental hepatology2013

Current status of immunosuppression in liver transplantation.

Narendra S Choudhary, Sanjiv Saigal, Rajat Shukla, Hardik Kotecha, Neeraj Saraf, Arvinder S Soin

Abstract readReview
In one paragraph

Review in Journal of clinical and experimental hepatology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Hepatobiliary quiz-8 (2013).Journal of clinical and experimental hepatology · 2013
    Article
  6. Hepatobiliary quiz-7 (2013).Journal of clinical and experimental hepatology · 2013
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Basics and Art of Immunosuppression in Liver Transplantation.Journal of clinical and experimental hepatology
    Review
  13. Article
  14. Review
  15. Long-term Management of the Adult Liver Transplantation Recipients.Journal of clinical and experimental hepatology
    Review
  16. Article
  17. Immunosuppressive Drugs in Liver Transplant: An Insight.Journal of clinical and experimental hepatology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Narendra S ChoudharyMedanta Institute of Liver Transplantation and Regenerative Medicine and Institute of Digestive and Hepatobiliary Sciences, Sector 38, Gurgaon, India.
Sanjiv SaigalMedanta Institute of Liver Transplantation and Regenerative Medicine and Institute of Digestive and Hepatobiliary Sciences, Sector 38, Gurgaon, India.
Rajat ShuklaDepartment of Gastroenterology, Army Hospital (R & R Hospital), Delhi, India.
Hardik KotechaMedanta Institute of Liver Transplantation and Regenerative Medicine and Institute of Digestive and Hepatobiliary Sciences, Sector 38, Gurgaon, India.
Neeraj SarafMedanta Institute of Liver Transplantation and Regenerative Medicine and Institute of Digestive and Hepatobiliary Sciences, Sector 38, Gurgaon, India.
Arvinder S SoinMedanta Institute of Liver Transplantation and Regenerative Medicine and Institute of Digestive and Hepatobiliary Sciences, Sector 38, Gurgaon, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With advancements in immunosuppressive strategies and availability of better immunosuppressive agents, survival rate following liver transplantation has improved significantly in the recent times. Besides improvements in surgical techniques, the most important factor that has contributed to this better outcome is the progress made in the field of immunosuppression. Over the last several years, the trend has changed to tailored immunosuppression with the aim of achieving optimal graft function while avoiding its undesirable side effects. Induction agents are no longer used routinely and the aim is to provide minimal immunosuppression in the maintenance phase. The present review discusses the various types of immunosuppressive agents, their mechanism of action, clinical utility, advantages and disadvantages, and their side effects in short and long-term. It also discusses about tailoring immunosuppression in presence of various situations such as renal dysfunction, metabolic syndrome, hepatitis C recurrence, cytomegalovirus infections and so on. The issue of chronic kidney disease and the available renal sparing immunosuppressive strategies has been particularly stressed upon. Finally, it discusses about the practical aspects of various immunosuppression regimens including drug monitoring.

Indexed as

ACR, acute cellular rejectionATP, adenosine triphosphateCKD, chronic kidney diseaseCNI, Calcineurin inhibitorFKBP12, FK506 binding proteinHCV, hepatitis C virusHLA, human leukocyte antigenIL-2, interleukin-2immunosuppressionliver transplantationMAP, mitogen activated proteinmetabolic syndromeMPA, mycophenolic acidMS, metabolic syndromemTORC1, mammalian target of rapamycin complex 1NFAT, nuclear factor of activated T cellsNF-kB, nuclear factor kappa BPTLD, post-transplant lymphoproliferative disease

Identifiers

PMID25755489
PMCPMC3940114

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.