ArticlePediatrics2015
Comorbidity of physical and mental disorders in the neurodevelopmental genomics cohort study.
Article in Pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 4 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
69 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Pooled it
- Digital Behavior Change Interventions for Younger Children With Chronic Health Conditions: Systematic Review.Journal of medical Internet research · 2020Pooled it
- Medical comorbidities in children and adolescents with autism spectrum disorders and attention deficit hyperactivity disorders: a systematic review.European child & adolescent psychiatry · 2017Pooled it
- Allergic diseases in children with attention deficit hyperactivity disorder: a systematic review and meta-analysis.BMC psychiatry · 2017Pooled it
- Functional somatic symptoms in preschool attention-deficit/hyperactivity disorder: a secondary analysis of data from a randomized controlled trial of parent training.European child & adolescent psychiatry · 2023Trial
- Challenges in Recruiting University Students for Web-Based Indicated Prevention of Depression and Anxiety: Results From a Randomized Controlled Trial (ICare Prevent).Journal of medical Internet research · 2022Trial
- Evaluation of a mental health drop-in centre offering brief transdiagnostic psychological assessment and treatment for children and adolescents with long-term physical conditions and their families: a single-arm, open, non-randomised trial.Evidence-based mental health · 2021Trial
- Physical illnesses, mental or neurodevelopmental disorders, and multimorbidity in children: results from the Canadian Health Survey on Children and Youth.Social psychiatry and psychiatric epidemiology · 2026Article
- Health Functioning Moderates the Association Between Chronic Conditions and Mental Illness in Childhood.Child: care, health and development · 2026Article
- Neurodevelopmental comorbidities in juvenile systemic autoimmune and autoinflammatory diseases.Nature reviews. Rheumatology · 2026Review
- Shared Genetic Liability across Systems of Psychiatric and Physical Illness.Nature communications · 2026Article
- Stability and change of psychopathology symptoms among youth with chronic physical illness: A latent transition analysis.Clinical child psychology and psychiatry · 2026Article
- Do Common Genetic Factors Underlie Comorbidity Between Migraine and Major Depressive Disorder in Youth?Pediatric neurology · 2025Article
- Mental health service contact in children with and without physical-mental multimorbidity.Social psychiatry and psychiatric epidemiology · 2025Article
- Novel Insights into Somatic Comorbidities in Children and Adolescents Across Psychiatric Diagnoses: An Explorative Study.Child psychiatry and human development · 2025Article
- Associations Between Family Factors and Mental Health Service Use Among Children with Physical Illness: the Mediating Role of Child Psychopathology Trajectories.Child psychiatry and human development · 2025Article
- Psychogenic fever and neurodevelopmental disorders among Japanese children.BioPsychoSocial medicine · 2024Article
- An Epidemiological Study of Physical-Mental Multimorbidity in Youth: Une étude épidémiologique de la morbidité physique-mentale chez les jeunes.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2024Article
- Advances in the etiology and neuroimaging of children with attention deficit hyperactivity disorder.Frontiers in pediatrics · 2024Review
- Response shift in parent-reported psychopathology in children with chronic physical illness.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
objectivesTo examine patterns of associations between a broad range of mental and physical conditions by using a large, systematically obtained pediatric registry.
methodsThe sample included 9014 youth ages 8 to 21 years (4349 males and 4665 females; 3585 aged <13 years, 3678 aged 13 to 18 years, and 1751 aged 19 to 21 years) from the Philadelphia Neurodevelopmental Cohort identified through pediatric clinics at the Children's Hospital of Philadelphia health care network by the Center for Applied Genomics. Measures were as follows: physical condition based on electronic medical records and interview data on 42 physical conditions of 14 organ systems/specialties and mental disorders based on an abbreviated version of the structured Kiddie-Schedule for Affective Disorders and Schizophrenia psychiatric diagnostic interview.
resultsThere was a direct association between the severity of the physical condition and most classes of mental disorders, as well as with functional impairment. Models adjusted for sociodemographic correlates, other physical and mental disorders, and false discovery and revealed broad patterns of associations between neurodevelopmental disorders with behavior disorders (odds ratio [OR]: 1.5; 95% confidence interval [CI]: 1.3-1.8; P < .004) and attention-deficit/hyperactivity disorder (OR: 3.1; 95% CI: 2.7-3.6; P < .0001), and neurologic/central nervous system conditions (OR: 1.3; 95% CI: 1.1-1.9; P < .05) with mood disorders and attention-deficit/hyperactivity disorder (OR: 1.3; 95% CI: 1.1-1.5; P < .001), and autoimmune/inflammatory conditions with mood disorders (OR: 1.4; 95% CI: 1.1-1.8, P < .05).
conclusionsFindings show the strong overlap between physical and mental conditions and their impact on severity and functional impairment in youth. Specific patterns of comorbidity have important implications for etiology. Prospective tracking of cross-disorder morbidity will be important to establish more effective mechanisms for prevention and intervention.
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