ReviewWiley interdisciplinary reviews. RNA
Cutting, dicing, healing and sealing: the molecular surgery of tRNA.
Review in Wiley interdisciplinary reviews. RNA. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Queuosine is incorporated into precursor tRNA before splicing.Nature communications · 2025Article
- Investigations into the Diversity and Distribution of tRNA and Phylogenetics of Translation Factors in Amoebozoa-InfectingViruses · 2025Article
- RNA modifying enzymes shape tRNA biogenesis and function.The Journal of biological chemistry · 2024Review
- Fungi of the order Mucorales express a "sealing-only" tRNA ligase.RNA (New York, N.Y.) · 2024Article
- Recognition of the tRNA structure: Everything everywhere but not all at once.Cell chemical biology · 2024Review
- Fungi of the order Mucorales express a "sealing-only" tRNA ligase.bioRxiv : the preprint server for biology · 2023Article
- The tRNA identity landscape for aminoacylation and beyond.Nucleic acids research · 2023Review
- Mutations in Drosophila tRNA processing factors cause phenotypes similar to Pontocerebellar Hypoplasia.Biology open · 2022Article
- Beyond protein modification: the rise of non-canonical ADP-ribosylation.The Biochemical journal · 2022Article
- Article
- Review
- Reconstitution of the human tRNA splicing endonuclease complex: insight into the regulation of pre-tRNA cleavage.Nucleic acids research · 2020Article
- Disruption of the RNA modifications that target the ribosome translation machinery in human cancer.Molecular cancer · 2020Review
- A novel 5'-hydroxyl dinucleotide hydrolase activity for the DXO/Rai1 family of enzymes.Nucleic acids research · 2020Article
- PARPs in genome stability and signal transduction: implications for cancer therapy.Biochemical Society transactions · 2018Review
- How the intracellular partitioning of tRNA and tRNA modification enzymes affects mitochondrial function.IUBMB life · 2018Review
- The role of intracellular compartmentalization on tRNA processing and modification.RNA biology · 2018Review
- Retrograde nuclear transport from the cytoplasm is required for tRNARNA biology · 2018Article
- ADP-ribosylation: new facets of an ancient modification.The FEBS journal · 2017Review
- Repairing tRNA termini: News from the 3' end.RNA biology · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
All organisms encode transfer RNAs (tRNAs) that are synthesized as precursor molecules bearing extra sequences at their 5' and 3' ends; some tRNAs also contain introns, which are removed by splicing. Despite commonality in what the ultimate goal is (i.e., producing a mature tRNA), mechanistically, tRNA splicing differs between Bacteria and Archaea or Eukarya. The number and position of tRNA introns varies between organisms and even between different tRNAs within the same organism, suggesting a degree of plasticity in both the evolution and persistence of modern tRNA splicing systems. Here we will review recent findings that not only highlight nuances in splicing pathways but also provide potential reasons for the maintenance of introns in tRNA. Recently, connections between defects in the components of the tRNA splicing machinery and medically relevant phenotypes in humans have been reported. These differences will be discussed in terms of the importance of splicing for tRNA function and in a broader context on how tRNA splicing defects can often have unpredictable consequences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.