ArticleScientific reports2015
"Roar" of blaNDM-1 and "silence" of blaOXA-58 co-exist in Acinetobacter pittii.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 33 citations in OpenAlex.
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- Characterization of the Diversity in Host Range of an Extensively Drug-Resistant (XDR) Type IV Secretion System-Encoding Plasmid inPathogens (Basel, Switzerland) · 2025Article
- Inhibition of EV71 replication by an interferon-stimulated gene product L3HYPDH.Virus research · 2024Article
- Genomic study ofFrontiers in microbiology · 2024Article
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- Municipal Wastewaters Carry Important Carbapenemase Genes Independent of Hospital Input and Can Mirror Clinical Resistance Patterns.Microbiology spectrum · 2022Article
- Emergence of Hybrid Resistance and Virulence Plasmids Harboring New Delhi Metallo-β-Lactamase inAntibiotics (Basel, Switzerland) · 2021Article
- Co-Existence of Carbapenemase-Encoding Genes in Acinetobacter baumannii from Cancer Patients.Infectious diseases and therapy · 2021Article
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- Insights into the complete genomes of carbapenem-resistantAccess microbiology · 2020Article
- Whole-Genome Analysis of Two Copies ofInfection and drug resistance · 2020Article
- Genetic Characterization of Plasmid-BornemSphere · 2019Article
- Detection of co-harboring OXA-58 and NDM-1 carbapenemase producing genes resided on a same plasmid from anIranian journal of basic medical sciences · 2019Article
- Two Phenotype-DifferentiatedFrontiers in microbiology · 2019Article
- Co-occurrence of carbapenemase encoding genes in Acinetobacter baumannii, a dream or reality?BMC microbiology · 2018Article
- AcinetobacterAntimicrobial agents and chemotherapy · 2018Article
- Insights on the Horizontal Gene Transfer of Carbapenemase Determinants in the Opportunistic Pathogen Acinetobacter baumannii.Microorganisms · 2016Review
- Increased prevalence of carbapenem resistant Enterobacteriaceae in hospital setting due to cross-species transmission of the bla NDM-1 element and clonal spread of progenitor resistant strains.Frontiers in microbiology · 2015Article
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7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acinetobacter pittii 44551 was recovered from a patient with gout combined with tuberculosis and was found to harbor the carbapenemase genes blaNDM-1 and blaOXA-58 on two different plasmids pNDM-44551 and pOXA58-44551, respectively. pNDM-44551 displayed high self-transferability across multiple bacterial species, while pOXA58-44551 was likely co-transferable with pNDM-44551 into A. baumannii receipts. pNDM-44551 was a close variant of the previously characterized pNDM-BJ01, and the blaNDM-1 gene cluster was arranged sequentially as orfA, ISAba14, aphA6, ISAba125, blaNDM-1, bleMBL, ΔtrpF, dsbC, tnpR, and zeta. pOXA58-44551 was a repAci9-containing plasmid, and blaOXA-58 was embedded in a 372F-ISAba3-like-blaOXA-58-ISAba3 structure. The mobile genetic platforms of blaNDM-1 and blaOXA-58 herein showed some differences from their previously characterized variants. The production of NDM-1 in strain 44551 contributed the majority to its high resistance to carbapenems, while the blaOXA-58 stayed silent most likely due to the lack of an upstream promoter to drive its transcription. Increased surveillance of Acinetobacter co-harboring blaNDM-1 (active) and blaOXA-58 (either active or silent) is urgently needed.
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