ArticleEuropean journal of immunology2015
ICOS is required for the generation of both central and effector CD4(+) memory T-cell populations following acute bacterial infection.
Article in European journal of immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- Tumor Microenvironment Drives the Cross-Talk Between Co-Stimulatory and Inhibitory Molecules in Tumor-Infiltrating Lymphocytes: Implications for Optimizing Immunotherapy Outcomes.International journal of molecular sciences · 2024Review
- A natural killer cell mimic against intracellular pathogen infections.Science advances · 2024Article
- Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8Immunity · 2022Article
- ICOS signaling promotes a secondary humoral response after re-challenge with Plasmodium chabaudi chabaudi AS.PLoS pathogens · 2020Article
- Regulatory Effect of Sishen Pill on Tfh Cells in Mice With Experimental Colitis.Frontiers in physiology · 2020Article
- A nomogram-based immunoprofile predicts overall survival for previously untreated patients with esophageal squamous cell carcinoma after esophagectomy.Journal for immunotherapy of cancer · 2018Article
- Early programming and late-acting checkpoints governing the development of CD4 T-cell memory.Immunology · 2018Review
- Trying to See the Forest through the Trees: Deciphering the Nature of Memory Immunity toFrontiers in immunology · 2018Review
- T Cells Primed by Live Mycobacteria Versus a Tuberculosis Subunit Vaccine Exhibit Distinct Functional Properties.EBioMedicine · 2018Article
- Vaccination establishes clonal relatives of germinal center T cells in the blood of humans.The Journal of experimental medicine · 2017Article
- Retention of Ag-specific memory CD4European journal of immunology · 2017Article
- Long-Lived CD4+IFN-γ+ T Cells rather than Short-Lived CD4+IFN-γ+IL-10+ T Cells Initiate Rapid IL-10 Production To Suppress Anamnestic T Cell Responses during Secondary Malaria Infection.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Loss of Immune Tolerance Is Controlled by ICOS in Sle1 Mice.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Development of interleukin-17-producing Vγ2+ γδ T cells is reduced by ICOS signaling in the thymus.Oncotarget · 2016Article
- Differentiation of ICOS+ and ICOS- recent thymic emigrant regulatory T cells (RTE T regs) during normal pregnancy, pre-eclampsia and HELLP syndrome.Clinical and experimental immunology · 2016Article
- ICOS Co-Stimulation: Friend or Foe?Frontiers in immunology · 2016Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Interactions between ICOS and ICOS ligand (ICOSL) are essential for the development of T follicular helper (Tfh) cells and thus the formation and maintenance of GC reactions. Given the conflicting reports on the requirement of other CD4(+) T-cell populations for ICOS signals, we have employed a range of in vivo approaches to dissect requirements for ICOS signals in mice during an endogenous CD4(+) T-cell response and contrasted this with CD28 signals. Genetic absence of ICOSL only modestly reduced the total number of antigen-specific CD4(+) T cells at the peak of the primary response, but resulted in a severely diminished number of both T central memory and T effector memory cells. Treatment with blocking anti-ICOS mAb during the primary response recapitulated these effects and caused a more substantial reduction than blocking CD28 signals with CTLA4Ig. During the memory phase of the response further signals through ICOS or CD28 were not required for survival. However, upon secondary challenge only Tfh cell expansion remained heavily ICOS-dependent, while CD28 signals were required for optimal expansion of all subsets. These data demonstrate the importance of ICOS signals specifically for memory CD4(+) T-cell formation, while highlighting the potential of therapeutically targeting this pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.