ArticleNeuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition2015
APOE ε4 genotype predicts memory for everyday activities.
Article in Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 9 citations in OpenAlex.
- The physiological effects of APOE genotype in healthy young/middle-aged individuals.Biological reviews of the Cambridge Philosophical Society · 2026Article
- Predicting the apolipoprotein E ε4 allele carrier status based on gray matter volumes and cognitive function.Brain and behavior · 2024Article
- APOE ε4/ε4 homozygotes with early Alzheimer's disease show accelerated hippocampal atrophy and cortical thinning that correlates with cognitive decline.Alzheimer's & dementia (New York, N. Y.) · 2020Article
- Frailty effects on non-demented cognitive trajectories are moderated by sex and Alzheimer's genetic risk.Alzheimer's research & therapy · 2019Article
- Impaired memory-guided attention in asymptomatic APOE4 carriers.Scientific reports · 2019Article
- Event Boundaries in Memory and Cognition.Current opinion in behavioral sciences · 2017Article
- Event segmentation improves event memory up to one month later.Journal of experimental psychology. Learning, memory, and cognition · 2017Article
- Event perception: Translations and applications.Journal of applied research in memory and cognition · 2017Article
- No effect of apolipoprotein E polymorphism on MRI brain activity during movie watching.Brain and neuroscience advancesArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The apolipoprotein E (ApOE) ε4 allele is associated with neuropathological buildup of amyloid in the brain, and with lower performance on some laboratory measures of memory in some populations. In two studies, we tested whether ApOE genotype affects memory for everyday activities. In Study 1, participants aged 20-79 years old (n = 188) watched movies of actors engaged in daily activities and completed memory tests for the activities in the movies. In Study 2, cognitively healthy and demented older adults (n = 97) watched and remembered similar movies, and also underwent structural MRI scanning. All participants provided saliva samples for genetic analysis. In both samples we found that, in older adults, ApOE ε4 carriers demonstrated worse everyday memory performance than did ε4 noncarriers. In Study 2, ApOE ε4 carriers had smaller medial temporal lobes (MTL) volumes, and MTL volume mediated the relationship between ApOE genotype and everyday memory performance. These everyday memory tasks measure genetically determined cognitive decline that can occur prior to a clinical diagnosis of dementia. Further, these tasks are easily administered and may be a useful clinical tool in identifying ε4 carriers who may be at risk for MTL atrophy and further cognitive decline that is a common characteristic of the earliest stages of Alzheimer's disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.