ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2015
Involvement of Endogenous Enkephalins and β-Endorphin in Feeding and Diet-Induced Obesity.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 50 citations in OpenAlex.
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- The Endogenous Opioid System in Compulsive Eating.Brain sciences · 2026Review
- Special Issue: "Recent Advances in Hypertension, Hypercholesterolemia and Type 2 Diabetes".Biomedicines · 2026Article
- Metabolic syndrome reduces but does not eliminate the cardioprotective effect of adaptation to hypoxia: the link with changes in the opioid system.Pflugers Archiv : European journal of physiology · 2025Article
- Licking microstructure behavior classifies a spectrum of emotional states in mice.Frontiers in systems neuroscience · 2025Article
- Distinct basal forebrain-originated neural circuits promote homoeostatic feeding and suppress hedonic feeding in male mice.Nature metabolism · 2024Article
- Enkephalins and Pain Modulation: Mechanisms of Action and Therapeutic Perspectives.Biomolecules · 2024Review
- Low resting metabolic rate and increased hunger due to β-MSH and β-endorphin deletion in a canine model.Science advances · 2024Article
- Lateral hypothalamic proenkephalin neurons drive threat-induced overeating associated with a negative emotional state.Nature communications · 2023Article
- The Role of Mu Opioid Receptors in High Fat Diet-Induced Reward and Potentiation of the Rewarding Effect of Oxycodone.Life (Basel, Switzerland) · 2023Article
- The Involvement of Endogenous Enkephalins in Glucose Homeostasis.Biomedicines · 2023Article
- Metabolic effects of lipectomy and of adipose tissue transplantation.Obesity (Silver Spring, Md.) · 2023Review
- The impact of SNP density on quantitative genetic analyses of body size traits in a wild population of Soay sheep.Ecology and evolution · 2022Article
- Connections of the mouse subfornical region of the lateral hypothalamus (LHsf).Brain structure & function · 2021Article
- The immune-opioid axis in prediabetes: predicting prediabetes with insulin resistance by plasma interleukin-10 and endomorphin-2 to kappa-opioid receptors ratio.Diabetology & metabolic syndrome · 2021Article
- Disruption of GABA or glutamate release from POMC neurons in the adult mouse does not affect metabolic end points.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Backstage of Eating Disorder-About the Biological Mechanisms behind the Symptoms of Anorexia Nervosa.Nutrients · 2020Review
- The Role of High Fat Diets and Liver Peptidase Activity in the Development of Obesity and Insulin Resistance in Wistar Rats.Nutrients · 2020Article
- The Opioid System and Food Intake: Use of Opiate Antagonists in Treatment of Binge Eating Disorder and Abnormal Eating Behavior.Journal of clinical medicine research · 2020Review
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Studies implicate opioid transmission in hedonic and metabolic control of feeding, although roles for specific endogenous opioid peptides have barely been addressed. Here, we studied palatable liquid consumption in proenkephalin knockout (PENK KO) and β-endorphin-deficient (BEND KO) mice, and how the body weight of these mice changed during consumption of an energy-dense highly palatable 'cafeteria diet'. When given access to sucrose solution, PENK KOs exhibited fewer bouts of licking than wild types, even though the length of bouts was similar to that of wild types, a pattern that suggests diminished food motivation. Conversely, BEND KOs did not differ from wild types in the number of licking bouts, even though these bouts were shorter in length, suggesting that they experienced the sucrose as being less palatable. In addition, licking responses in BEND, but not PENK, KO mice were insensitive to shifts in sucrose concentration or hunger. PENK, but not BEND, KOs exhibited lower baseline body weights compared with wild types on chow diet and attenuated weight gain when fed cafeteria diet. Based on this and related findings, we suggest endogenous enkephalins primarily set a background motivational tone regulating feeding behavior, whereas β-endorphin underlies orosensory reward in high need states or when the stimulus is especially valuable. Overall, these studies emphasize complex interplays between endogenous opioid peptides targeting μ-receptors, such as enkephalins and endorphins, underlying the regulation of feeding and body weight that might explain the poor efficacy of drugs that generally target μ-opioid receptors in the long-term control of appetite and body weight.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.